MMP-7在肝细胞癌组织中的表达及临床意义  

Clinical significance of matrix metalloproteinase-7 expression in hepatocellular carcinoma

作　　者：饶雪峰[1] 刘伟中[1] 廖传文[1] 彭贵祖[2] 单人锋[2] 

机构地区：[1]江西省人民医院普外科,江西省南昌市330006 [2]南昌大学一附医院普外科,江西省南昌市330006

出　　处：《世界华人消化杂志》2009年第28期2903-2907,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨基质金属蛋白酶7(MMP-7)与肝细胞癌(HCC)生物学行为及预后的关系,试图阐明HCC的发生发展和微转移机制,并了解其预后.方法:应用ElivisionTMplus二步法(AB法)免疫组织化学检测CD34和MMP-7单克隆抗体在63例HCC、10例肝硬化和10例正常肝组织标本的表达,分析MMP-7表达与HCC临床病理因素之间的关系.结果:MMP-7在HCC组织中的表达明显高于肝硬化和正常肝组织,差异有显著性统计学意义(χ2=21.19,P<0.05);MMP-7的表达与HCC的大小、病灶数目、浸润、血管癌栓、临床分期和肿瘤血管生成具有相关性(χ2=7.1,14.55,4.24,4.49,7.11,t=4.30,均P<0.05).结论:MMP-7可能在HCC的发生发展过程中起重要作用.MMP-7促进HCC浸润转移和血管生成,可成为临床判定预后的良好指标.AIM：To investigate the clinical significance of matrix metalloproteinase-7 （MMP-7） expression in hepatocellular carcinoma （HCC） and analyze the correlation of MMP-7 expression with some pathologic parameters in HCC.METHODS：Sixty-three HCC specimens,10 hepatic cirrhosis specimens and 10 normal liver tissue specimens were used in the study.Immunohistochemistry was used to detect MMP-7 expression and microvessel density in these specimens.The correlation of MMP-7 expression with some pathologic parameters in HCC was analyzed.RESULTS： MMP-7 expression level was significantly higher in HCC than in hepatic cirrhosis and normal liver tissue （χ^2= 21.19, P 〈 0.05）. MMP-7 expression was correlated with tumor size and number, vascular cancer embolus, invasion, tumor stage and angiogenesis （χ^2 = 7.1, 14.55, 4.24, 4.49 and 7.11, respectively; t = 4.30, all P 〈 0.05）, but was not correlated with serum alpha-fetoprotein, age and sex （all P 〉 0.05）. CONCLUSION： MMP-7 may play a critical role in the development, progression, metastasis and angiogenesis of HCC. MMP-7 expression can be used as an important prognostic factor for HCC.

关 键 词：肝细胞癌 基质金属蛋白酶7 微血管密度 

分 类 号：R735.7[医药卫生—肿瘤] R735.2[医药卫生—临床医学]