前部缺血性视神经病变患者治疗前后多焦视觉诱发电位检测结果分析  

Analysis of the results of multifocal visual evoked potential examination in patients with anterior ischemic opticneuropathy before and after treatment

作　　者：刘向芹[1] 郭晓文 周丽霞[1] 

机构地区：[1]哈尔滨二四二医院眼科,150066 [2]齐齐哈尔市五官医院眼科

出　　处：《中华眼底病杂志》2009年第6期437-439,共3页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的 观察前部缺血性视神经病变（AION）治疗前后多焦视觉诱发电位（mfVEP）的检查结果，初步探讨其临床应用意义。方法 对AION患者90例90只眼进行mfVEP检测，分析mfVEP的二阶反应，将反应分上、下半侧视野，及鼻上、鼻下、颞上、颞下4个象限视野；分析各反应总和波，对各区域进行比较。观察AION眼与对侧眼及AION眼治疗前后各部分的波形特征。结果 治疗前AION眼病变受累区域mfVEP P波振幅及潜伏期分别为0.198±0.033、100.197±7.354，对侧眼相应区域分别为0.271±0.024、98.567±6.794，两者比较差异均有统计学意义（t=16.556，18.330；P〈0.01）。治疗后AION眼病变区域P波振幅及潜伏期分别为0.229±0.016、100.104±10.603，与治疗前相比，差异均有统计学意义（t=7.622，5.501；P〈0.01）；与对侧眼相比差异均有统计学意义（t=13.649，8.858；P〈0.01）。结论 mfVEP P波振幅及潜伏期能够准确反映AION患眼治疗前后局部视神经损害及恢复情况，具有良好的可重复性。可以作为AION诊断及检测预后的新方法。Objective To observe the results of multifocal visual evoked potential （mfVEP） examination in patients with anterior ischemic optic neuropathy （AION） before and ater treatment, and to probe its clinical significance. Methods A total of 90 patients （90 eyes） with AION were examined by mfVEP; the secondorder reaction of mfVEP was analyzed.The reaction was divided into upper and lower hemi field of visual field, or 1/4 quadrant visual field （superior nasal, inferior nasal, superior temporal, and inferior temporal）. The sum of waves of each response was analyzed and the results in various regions were compared.The features of wave configuration was compared between the AION eyes and the contralateral eye, and between the AION eyes before and after treatment.Results The amplitude and latency of P-wave of mfVEP was 0.198±0.033 and 100.197±7.354 respectively in AION eyes before treatment, and was 0.271±0.024 and 98.567±6.794 in the contralateral eyes; the difference was significant （t=16.556,18.330; P〈0.01）. The amplitude and latency of P-wave of mfVEP was 0.229±0.016 and 100.104±10.603 respectively in AION eyes after treatment, which differed much from that before the treatment （t=13.649, 8.858; P〈0.01） and also from that of the contralateral eyes （t=13.649,8.858;P〈0.01）. ConclusionsThe amplitude and latency of P-wave of mfVEP may accurately reflect the recovery of local optic nerve damage in AION eyes before and after treatment with good repeatability. AION can be used as a new method for AION diagnosis and detection of the prognosis.

关 键 词：诱发电位 视觉 视神经病变 缺血性/治疗 视野检查法/利用 

分 类 号：R774.6[医药卫生—眼科]