血管内皮细胞生长因子家族及其受体与表皮黑素瘤的关系  

Relationship of epidermal melanoma with vascular endothelial cell growth factors （VEGFs） and their receptors

作　　者：杨萍[1] 郑敏[1] 

机构地区：[1]浙江大学医学院附属第二医院皮肤科,杭州310009

出　　处：《国际皮肤性病学杂志》2009年第6期385-387,共3页International Journal of Dermatology and Venereology

摘　　要：血管内皮细胞生长因子家族及其受体对表皮黑素瘤的主要作用有促黑素瘤细胞增殖，促内皮细胞增殖及新生血管形成，增加血管通透性，以及促黑素瘤相关淋巴管新生等。组织及血清血管内皮细胞生长因子水平对病情进展程度及疗效的判断及预后具有一定意义。近年来，以血管内皮细胞生长因子家族为靶点，采用各种方法抑制血管内皮细胞生长因子表达，阻断血管内皮细胞生长因子及其受体相互作用，抑制血管内皮细胞生长因子受体酪氨酸激酶活性，阻断信号转导，已显示出治疗表皮黑素瘤的巨大潜在价值。VEGFs and VEGF receptors （VEGFR） play an important role in the development of epidermal melanoma. For example, they can accelerate the proliferation of melanoma cells and endothelial cells, promote neovascularization and melanoma-associated lymphogenesis, increase vascular permeability, etc. The levels of tissue and serum VEGFs have some values in the evaluation of disease progress, treatment efficacy and prognosis. Recently, it has shown vast potentials in the treatment of epidermal melanoma to inhibit the expression of VEGFs, block the interaction between VEGFs and VEGFR, suppress the activation of tyrosinase by VEGFR and to interrupt the signaling transduction with VEGFs as the target.

关 键 词：内皮细胞 受体 生长因子 表皮 黑色素瘤 

分 类 号：R739.5[医药卫生—肿瘤]