中药桂皮醛对口腔致龋菌的体外抑菌活性研究  

Antibacterial activities of Chinese medicine cinnamicaldehyde against main periodontal pathogens

作　　者：杨霞[1] 黄萍[2] 李丛华[1] 

机构地区：[1]重庆医科大学附属口腔医院口腔内科教研室,重庆400015 [2]四川大学华西口腔医学院牙周科,成都610041

出　　处：《重庆医科大学学报》2009年第10期1409-1410,共2页Journal of Chongqing Medical University

摘　　要：目的:探讨桂皮醛对主要致龋菌的抗菌活性。方法:采用琼脂稀法药敏敏感试验,测定桂皮醛对主要致龋菌的最小抑菌浓度(Minimal inhibitive concentration,MIC)和最小杀菌浓度(Minimal bacterecdal concentration,MBC)。结果:桂皮醛能明显抑制分离的50株临床株,其MIC值在(32～256)mg/L之间,微荣球菌(V.parvula)的平均最低抑菌浓度为(139.000±0.026)mg/L;丙酸杆菌(P.propionicum)的平均最低抑菌浓度为(128.000±0.000)mg/L;颊纤毛菌(L.buccalis)的平均最低抑菌浓度为(213.000±0.027)mg/L;变形链球菌(S.mutans)的平均最低抑菌浓度为(213.00±0.021)mg/L;粘性放线菌(A.viscosus)的平均最低抑菌浓度为(148.00±0.021)mg/L。Objective： To evaluate the antibacterial activity of cinnamicaldehyde against the main periodontal pathogens in vitro.Methods：Agar dilution method for antimicrobial susceptibility testing was used to determine the minimal inhibitive concentration（MIC） of cinnamicaldehyde against the main periodontal pathogen.Results：The growth of 50 bacteria were inhibited completely by cinnamicaldehyde;the MIC of it on V.parvula were（139.000±0.026） mg/L and on P.propionicum were（128.000±0.000） mg/L;the MIC of it on L.buccalis were （213.000± 0.027 ） mg/L, the MIC of S.mutans were（213.000 ± 0.021 ） mg/L,he MIC of A.viscosus were（ 148.000 ± 0.021 ） mg/L. Conclusion： Cinnamicaldehyde has significant antibacterial activities on the main periodontal pathogens.

关 键 词：致龋菌 桂皮醛 琼脂稀释法 MIC 

分 类 号：R780.2[医药卫生—口腔医学]