脑血流灌注半定量法显像评价高压氧联合药物治疗一氧化碳中毒迟发性脑病疗效  

Cerebral perfusion semi-quantitative imaging for assessing the treatment of delayed encephalopathy from carbon monoxide poisoning

作　　者：熊冰[1] 周游[1] 蔡亚利[2] 刘洪彪[3] 汤中泉[4] 孙达[3] 徐昕[1] 刘文明[4] 

机构地区：[1]浙江大学附属第二医院康复医学科,杭州310009 [2]浙江大学附属第二医院放射科,杭州310009 [3]浙江大学附属第二医院核医学科,杭州310009 [4]浙江大学附属第二医院高压氧科,杭州310009

出　　处：《中华物理医学与康复杂志》2009年第11期756-759,共4页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的对比研究一氧化碳中毒后迟发性脑病（DEACMP）患者在高压氧（HBO）联合药物治疗前、后单光子发射计算机断层成像（SPECT）脑血流灌注显像结果，并对其优越性及临床意义进行评价。方法34例DEACMP患者接受20～40次HBO联合药物治疗，并在治疗前、后用双半胱乙酯（^99mTc-ECD）脑SPECT血流灌注扫描半定量法进行疗效监测和对比分析。结果HBO治疗后，DEACMP患者脑血流灌注减低区有明显改善，脑SPECT血流灌注半定量值与治疗前比较，差异有统计学意义（P〈0．05），而治疗前、后脑磁共振显像无明显差异。结论脑SPECT血流灌注半定量法显像在DEACMP的诊断和HBO治疗的疗效监测中可起重要作用。Objective To evaluate the effects of hyperbaric oxygen （HBO） combined with drug therapy on patients with delayed encephalopathy caused by carbon monoxide poisoning （COP）. Methods Twenty to forty sessions of HBO therapy were used to treat 34 COP patients. Assessment relied on ^99mTc-ethyl cysteinate dimer （ ^99mTc- ECD） single photon emission computed tomography （SPECT） imaging of cerebral perfusion before and after treatment. Results After HBO therapy, cerebral perfusion in the COP patients improved significantly. There was a significant difference of the SPECT images before and after treatment. Conclusions SPECT imaging of cerebral perfusion can play an important role in the diagnosis of delayed eneephalopathy caused by carbon monoxide poisoning, and it can be used for the therapeutic surveillance of HBO treatment.

关 键 词：高压氧 一氧化碳中毒迟发性脑病 单光子体层摄影术 

分 类 号：R747.9[医药卫生—神经病学与精神病学]