口腔鳞癌中肿瘤坏死因子-α表达与肿瘤血管生成的关系  

Correlation between Expressions of Tumor Necrosis Factor-α and Angiogenesis in Human Oral Squamous Cell Cancer

作　　者：杨建斌[1] 邵月保[1] 魏东义[1] 冯红超[2] 宋宇峰[2] 

机构地区：[1]新乡医学院第一附属医院口腔科,河南卫辉453100 [2]贵阳医学院附属医院口腔科

出　　处：《肿瘤防治研究》2009年第11期925-927,共3页Cancer Research on Prevention and Treatment

基　　金：贵州省第二批跨世纪人才省政府专项基金资助项目[黔科合人专字(2000)9813号]

摘　　要：目的将口腔鳞癌、癌旁组织内肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)的表达及微血管计数进行比较,探讨TNF-α表达与肿瘤血管生成的关系。方法应用免疫组织化学方法检测41例口腔鳞癌和10例癌旁组织中TNF-α的表达和微血管计数。结果口腔鳞癌中TNF-α的表达和微血管计数较癌旁组织均增加(P<0.01),随TNF-α表达的增加,微血管计数增加(P<0.01)。结论TNF-α在口腔鳞癌的血管生成中起重要作用,阻断TNF-α的分泌可能抑制肿瘤的血管生成。Objective Many investigations have showed that tumor necrosis factor-α（TNF-α）participated into tumor angiogenesis. By exploring the expression of TNF-α and angiogenesis in oral squamous cell cancer（OSCC） and pericancerous tissue, we studied the correlation of the expression of TNF-α and angiogenesis.Methods The expression of TNF-α and microvessel counts were assessed by immunohistochemical methods of SABC in paraffin section of 41 OSCC and 10 cases of pericancerous tissues.Results The expression of TNF-α in the OSCC group was significantly higher than that in the pericancerous group（P〈0.01）; microvessel counts in OSCC group was higher than that in the pericancerous group（P〈0.01）.The expression of TNF-α was significantly correlated to the microvessal counts（P〈0.01）.Conclusion TNF-α play a key role in angiogenesis of OSCC. But its mechanism and clinical significance need further investigations.

关 键 词：口腔鳞癌 肿瘤血管生成 肿瘤坏死因子-α(TNF-α) 

分 类 号：R739.8[医药卫生—肿瘤] R730.21[医药卫生—临床医学]