化疗相关性白细胞减少等因素对小细胞肺癌生存期的影响  

Impact of CIL on Survival of Patients with Small Cell Lung Cancer

作　　者：李芳[1] 胡成平[1] 顾其华[1] 黄瓅[1] 李伟[1] 

机构地区：[1]中南大学湘雅医院呼吸内科,长沙410007

出　　处：《肿瘤防治研究》2009年第11期961-965,共5页Cancer Research on Prevention and Treatment

摘　　要：目的探讨影响小细胞肺癌(small cell lung cancer,SCLC)患者生存期的因素。方法回顾性研究123例SCLC患者的临床资料,利用SPSS15.0统计软件Cox回归模型分析性别、年龄、吸烟、合并症、临床分期、ECOG评分、治疗方法、CEA、化疗相关性白细胞减少(chemotherapy-induced leucopenia,CIL)9个预后因素对生存期的影响。结果随访1～52月,死亡103例。6月、1年、2年、3年、4年存活率分别为70.7%、34.1%、8.94%、2.4%、0.8%,中位生存期11月[95%CI(9.328,12.627)]。Cox回归多因素分析显示,影响预后的独立因素是:ECOG评分(P=0.000)、化疗联合放疗(P=0.000)、临床分期(P=0.024)、CIL(P=0.013)。结论临床分期早、ECOG评分低、接受化疗联合放疗且出现CIL的SCLC患者生存期长、预后好。Objective The objective of this study is to discuss the independent prognostic factors in the patients of smallcell lung cancer（SCLC）. Methods One hundred and twenty-three patients of SCLC were reviewed. The potential prognostic factors such as： gender, age,smoke,complication,clinical stage, ECOG performance status,treatment,CEA,chemotherapy induced leucopenia（CIL） were analyzed by Cox regression using SPSS15.0 software. Results After 1 to 52 months follow-up,103 patients died. The surival rate in 6 month, 1st year, 2nd year, 3rd year and 4th year were 70.7%,34.1%,8.94%,2.4%and 0.8%,respectively. Median survival time（MST） was 11 months[95%CI（9.328, 12.627）].Cox regression showed that the independent prognostic factors on the surival time were ECOG performance status （P=0.000）, chemoradiotherapy （P=0.000）, clinical stage （P=0.024）, and CIL （P=0.013）.Conclusion Patients of SCLC, who are in limited clinic stage,with low ECOG performance status,have been treated with chemoradiotherapy and showed CIL, will prolong the survival time （P〈0.05） and have a better life quality.

关 键 词：小细胞肺癌 生存期 化疗相关性白细胞减少 

分 类 号：R734.2[医药卫生—肿瘤] R45[医药卫生—临床医学]