肿瘤坏死因子-α和白细胞介素-6、-8、-18水平的变化与急性脑梗死的关系  

Association between serum TNF-α,IL-6,IL-8 and IL-18 levels and acute cerebral infarction

作　　者：左雪梅[1] 韦欣[1] 胡纪[1] 

机构地区：[1]上海市长宁区中心医院检验科,上海200336

出　　处：《诊断学理论与实践》2009年第5期531-534,共4页Journal of Diagnostics Concepts & Practice

摘　　要：目的:探讨急性脑梗死(ACI)患者血清TNF-α、IL-6、IL-8和IL-18水平变化和临床意义。方法:用酶联免疫吸附试验测定107例ACI患者和110名对照者血清TNF-α、IL-6、IL-8和IL-18水平。结果:ACI组患者的血清TNF-α、IL-6、IL-8和IL-18水平明显高于对照组的(P<0.05);轻型组、中型组、重型组ACI患者血清TNF-α、IL-6、IL-8和IL-18逐渐升高(P<0.05);且与临床神经功能缺损程度评分呈正相关。结论:ACI患者血清TNF-α、IL-6、IL-8和IL-18水平升高,且与临床神经功能缺损程度密切相关,有助于判断ACI患者病情。Objective To study the levels of serum tumor necrosis factor-alpha（TNF-α）, interleukin-6（IL-6）, interleukin-8 （IL-8） and interleukin-18 （IL-18） and their clinical significance in patients with acute cerebral infarction. Method Levels of serum TNF-α, IL-6, IL-8 and IL-18 were measured by enzyme-linked immunosorbent assay （ELISA） in 107 patients with acute cerebral infarction,and 110 normal adults were served as control. Results The levels of serum TNF-α, IL-6, IL-8 and IL-18 were higher in ACI group than in controls （P〈0.05）. The levels of TNF-α, IL -6, IL-8 and IL-18 gradually increased with the increase in severity of ACI （P〈0.05）; and the score of clinical neurological deficit was positively correlated with the levels of TNF-α, IL-6, IL-8 and IL-18. Conclusions Serum TNF-α, IL-6, IL-8 and IL-18 levels were increased in patients with ACI, and were positively correlated with the score of clinical neurological deficit. It could be used for helping the judging of severity of ACI.

关 键 词：肿瘤坏死因子-Α 白细胞介素-6 白细胞介素-8 白细胞介素-18 急性脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R446.11[医药卫生—临床医学]