B类1型清道夫受体表达调控与信号转导通路  

Expression Regulation and Signal Transduction of Scavenger Receptor Class B Type 1

作　　者：张青海[1] 易光辉[1,2] 李媛彬[1] 阮长耿[2] 

机构地区：[1]南华大学心血管病研究所,动脉硬化学湖南省重点实验室,衡阳421001 [2]苏州大学附属第一医院江苏省血液研究所,苏州215006

出　　处：《中国生物化学与分子生物学报》2009年第11期1003-1009,共7页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.30570958);中国博士后科学基金项目(No.20060400953)~~

摘　　要：B类1型清道夫受体(scavenger receptor class Btype1,SR-B1)是一种与清道夫受体CD36具有高度同源性的膜糖蛋白,其表达相对广泛且有着众多生物学作用.体内外多种因素可从转录或转录后水平对SR-B1表达进行调控:PPARα/γ激动剂、部分LXR激动剂、LH/HCG、雌激素等能上调SR-B1的表达;维生素E、INFα、脂多糖、IGF-1、胆酸、PXR激动剂及高糖水平等能下调SR-B1的表达;而血管紧张素Ⅱ则可对SR-B1的表达进行双向调节,且它们具体的调节机制复杂.SR-B1作为一种具有多配体结合特性的膜受体,不同配体与其结合后可介导细胞内不同信号事件及生物学效应,如介导HDL激活细胞内PI3K/Akt及MAPK信号途径,增加内皮型一氧化氮合酶的磷酸化、促进内皮细胞迁移与内皮重构.此外,非HDL类配体如LDL激活p38MAPK途径、凋亡细胞、血清淀粉样蛋白A等激活胞内MAPK途径均可由SR-B1介导.本文对近年来B类1型清道夫受体表达调控机制及信号转导通路的相关研究进行综述.Scavenger receptor class B type 1 （SR-B1） is a membrane glycoprotein with multiple biological functions and a high homology to scavenger receptor CD36. A variety of factors may affect SR-B1 expression at the transcription or post-transcriptional level in vivo and in vitro. PPARα/γ agonists, certain LXR agonists, LH/HCG and estrogen up-regulate the SR-B1 expression, whereas vitamin E, INFα, lipopolysaceharide, IGF- 1, bile acid, PXR agonist and hyperglycemia down-regulate its expression. Angiotensin Ⅲ affects regulates the expression of SR-B1 in a bidirectional manner, as the specific mechanism involved is highly complicated. As a multi-ligand-binding membrane receptor, distinct intraeellular signaling events and biological effects id mediated by different ligands, for instance, HDL-activated PI3K/Akt and MAPKs signaling pathway is responsible to increase the phosphorylation of eNOS and promote the migration of endothelial cell and endothelial reconstruction. Furthermore, SR-B1 is also involved in LDL-activated p38MAPK pathway, apoptotic ceils and serum amyloid. The recent progress on the understanding of SR-B1 expression regulation and signal transduction is reviewed.

关 键 词：B类1型清道夫受体 表达调控 信号转导 丝裂原激活蛋白激酶 蛋白激酶B 

分 类 号：R363[医药卫生—病理学]