丙泊酚对大鼠肝缺血再灌注后肺组织损伤保护作用  

Protective effects of propofol on lung Injury from hepatic ischemia-reperfusion in rats

作　　者：盖毅文[1] 来炳祺 成少利[3] 王升儒[3] 吴夏慧[3] 

机构地区：[1]西安交通大学医学院第一附属医院麻醉科,陕西西安710061 [2]陕西省肿瘤医院麻醉科,陕西西安710061 [3]西安交通大学医学院,陕西西安710061

出　　处：《现代肿瘤医学》2009年第11期2068-2070,共3页Journal of Modern Oncology

基　　金：陕西省社发公关项目资助[编号:2006K12-G5(3)]

摘　　要：目的:研究全身麻醉药丙泊酚对大鼠肝缺血再灌注后肺损伤的保护作用。方法:将20只SD大鼠随机分为2组,对照组和丙泊酚静脉注射组(实验组),每组10只,各组均用氯胺酮(1mg/kg)基础麻醉。对照组直接进行手术,实验组加用丙泊酚维持麻醉,同时进行手术。两组肝脏缺血再灌注后取肺脏灌洗液以及肺组织标本。观察肺组织的形态学改变并测定肺组织和肺泡灌洗液NF-κB的含量。结果:丙泊酚用于实验动物维持麻醉,可以有效地降低肺组织以及肺泡灌洗液中NF-κB的含量。结论:丙泊酚对肝缺血再灌后的肺组织具有保护作用。Objective：To study the protective effects of propofol on lung injury from hepatic ischemia - reperfusion in rats. Methods ：Twenty rats were randomly divided into two groups with 10 rats in each group. All animals in the two groups were conducted basic anesthesia with ketamine （1 mg/kg） ,while the rats in experimental group were administrated by propofol to maintain anesthesia during surgery. After hepatic ischemia - reperfusion, lung lavage fluid and lung tissue were sampled. The morphological changes in the lung tissues immunohistochemically observed and NF - κB in lung tissue and lavage fluid were determined by western - blotting in two groups. Results： Propofol anesthesia during hepatic ischemia - reperfusion in rats was effective in reducing NF -κB in lung tissue and lavage fluid. Conclusion：Propofol has a protective effect on lung injury from hepatic ischemia- reperfusion in rats.

关 键 词：丙泊酚 肝缺血再灌注 肺损伤 

分 类 号：R730.53[医药卫生—肿瘤]