COX-2、VEGF-C在甲状腺乳头状癌中的表达及临床意义  

Expression and significance of cyclooxygenase-2 and vascular endothelial growth factorc in papillary carcinoma of the thyroid

作　　者：张喜军[1] 张杰武[1] 管强[1] 

机构地区：[1]哈尔滨医科大学附属第四医院耳鼻喉科,黑龙江哈尔滨150001

出　　处：《现代肿瘤医学》2009年第11期2107-2110,共4页Journal of Modern Oncology

摘　　要：目的:研究环氧化酶-2(cyclooxygenase-2,COX-2)、血管内皮生长因子C(vascular endothelialgrowth factor-C,VEGF-C)在甲状腺乳头状癌中的表达及两者间相互关系,结合临床病理资料,初步探讨COX-2和VEGF-C在甲状腺乳头状癌发生发展中的作用及临床意义。方法:应用免疫组化SP法检测49例甲状腺乳头状癌及34例正常甲状腺组织的COX-2、VEGF-C蛋白表达情况,分析甲状腺乳头状癌中COX-2、VEGF-C的表达与临床病理特征及颈部淋巴结转移之间的关系。结果:COX-2和VEGF-C阳性表达都主要定位于细胞浆。49例甲状腺乳头状癌组织中COX-2和VEGF-C蛋白的阳性表达率分别为63.3%和55.1%,34例甲状腺正常组织中COX-2和VEGF-C蛋白的阳性表达率分别为6.25%和20.6%。两种蛋白在甲状腺乳头状癌与甲状腺正常组织中的阳性表达率之间均具有显著性差异(P<0.01)。COX-2和VEGF-C蛋白的阳性表达率与淋巴结转移,临床分期显著相关(P<0.01),但与患者性别、年龄、肿瘤大小之间无相关性(P>0.05)。COX-2的阳性表达和VEGF-C的阳性表达呈正相关(P<0.05)。结论:COX-2、VEGF-C的高表达在甲状腺乳头状癌的发生发展过程中起重要的作用,检测其表达对判断临床进展以及推测预后有一定的参考价值。Objective： To investigate the expression and sigmificance of cyclooxygenase - 2 （ COX - 2 ） and vascular endothelial growth factor - c（VEGF - C）in papillary carcinoma of the thyroid,and correlation of COX -2 and VEGF - C. Methods ： Cox - 2 and VEGF - C expressions were detected in 49 thyroid papillary carcinoma and 34 normal thyroid tissue samples by immunohistochemical method to analyze the correlation between the protein expression rate and clinical and pathological characters and to study the correlation between the expression of COX - 2 and VEGF - C. Results：Expression of two oncogenes was significantly different between papillary carcinoma of the thyroid tissues and normal thyroid tissues （P 〈 0.01 ）. The positive expression rates of COX -2 and VEGF - C were associated with cervical lymph node metastasis and clinical stage （P 〈 0.01 ） , but not associated with sex , age, primary site of the tumor（P 〉 0.05 ）. The positive expression of COX- 2 closely related to the expression of VEGF- C （P 〈 0.01 ）. Conclusion： Overexpression of COX - 2 and VEGF - C plays an important role in progress of papillary carcinoma of the thyroid ,which may also help to predict the prognosis of the carcinoma.

关 键 词：甲状腺乳头状癌 COX-2 VEGF—C 免疫组化 

分 类 号：R736.1[医药卫生—肿瘤]