胰腺实性假乳头状瘤与非功能性胰岛细胞瘤临床分析  

Differentiation of solid-pseudopapillary tumor and nonfunctional islet cell tumor of pancreas

作　　者：陈绍勤[1,2] 邹声泉[2] 李宏[2] 张海云[3] 郑正荣[4] 戴起宝[1] 

机构地区：[1]福建医科大学附属第一医院胃肠外科,福建福州350005 [2]华中科技大学同济医学院附属同济医院普外科,湖北武汉430030 [3]福建省泉州市第一医院肿瘤外科,福建泉州362000 [4]福建医科大学附属第二医院肿瘤外科,福建泉州362000

出　　处：《现代肿瘤医学》2009年第11期2182-2184,共3页Journal of Modern Oncology

摘　　要：目的:研究胰腺实性假乳头状瘤(SPTP)与非功能性胰岛细胞瘤(NICT)的临床症状、血清学指标和影像学表现,探讨如何进行鉴别诊断。方法:回顾性分析17例SPTP与10例NICT的临床诊治情况。结果:SPTP患者平均23.8±6.5岁,女性占88.2%(15/17),70.6%(12/17)无明显症状,NICT患者平均43.5±9.3岁,女性占70%(7/10),30%(3/10)无明显症状,两组在年龄、性别和临床症状方面的差异有统计学意义(P<0.05)。SPTP组肿瘤直径平均9.5±3.4cm,NICT组肿瘤直径平均9.1±3.9cm;两组在肿瘤大小和血清肿瘤标志物水平方面的差异无统计学意义(P>0.05)。SPTP的CT平扫影像可见囊性与实性成分相间,增强扫描动脉期肿瘤实性成分呈现轻微强化,静脉期强化稍强;NICT的CT平扫影像显示为实性成分为主的肿瘤,增强扫描动脉期肿瘤的实性部分均明显强化,静脉期强化稍减弱;NICT的强化比SPTP明显。结论:综合分析临床表现和CT等影像学检查有助于SPTP与NICT的鉴别诊断。Objective：To investigate the differentiation of clinical manifestation, serological test and application of imaging detection between solid -pseudopapillary tumor of the pancreas （SPTP） and nonfunctional islet cell tumor （NICT）. Methods： We retrospectively reviewed data of seventeen patients with SPTP and ten patients with NICT. Results： SPTP patients had a mean age of 23.8 ± 6.5 years,88.2% female and 70. 6% patients without obvious clinical manifestations, while NICT patients had a mean age of 43.5 ± 9.3,70% female and 30% patients without obvious clinical manifestations. There were significant differences in ages, gender and clinical symptoms between two groups （ P 〈 0.05 ）. SPTP were 9.5 ±3.4 cm in diameter on average, while NICT were 9.1± 3.9 cm in diameter on average. There were no significant differences in size and serum tumor marker level between two groups （ P 〉 0.05 ）. On pre - contrast CT scan, SPTP demonstrated mixed with solid and cystic structures. The solid portions of SPTP was slightly enhanced in the arterial phase and markedly enhanced in the portal venous phase on post - contrast CT scan. However, NICT demonstrated the tumors which were mainly composed of solid portions on pre - contrast CT scan. NICT was markedly enhanced in the arterial phase and slightly enhanced in the portal venous phase on post - contrast CT scan. NICT attention was higher than that of SPTP on post - contrast CT scan. Conclusion： Clinical symptom and CT scan are of great value in the differential diagnosis between SPTP and NICT.

关 键 词：胰腺肿瘤 胰腺实性假乳头状瘤 非功能性胰岛细胞瘤 诊断 体层摄影术 鉴别诊断 

分 类 号：R735.9[医药卫生—肿瘤]