HBV DNA阳性肝癌患者血清HBeAg检测与肝细胞癌复发转移的关系  

Relationship between the level of HBeAg and the metastasis in hepatocarcinoma patients with HBV DNA

作　　者：陈健[1] 施民新[2] 刘继斌[1] 

机构地区：[1]江苏省南通大学附属肿瘤医院,江苏南通226361 [2]新疆伊犁州友谊医院,新疆伊犁835000

出　　处：《现代肿瘤医学》2009年第11期2187-2189,共3页Journal of Modern Oncology

摘　　要：目的:研究HBVDNA阳性肝癌(HCC)患者血清HBeAg检测与肝细胞癌复发转移的关系。方法:HBVDNA阳性HCC肝切除术患者60例,HBVDNA阴性HCC肝切除术患者60例。60例HBVDNA阳性HCC患者中依据肿瘤病灶局限、肉眼以及镜下均无肝内播散和门静脉浸润的低侵袭组,共28例;肿瘤组织伴有多发性肝内播散和(或)门静脉主肝癌栓者为高侵袭组,共32例。检测患者术前及术后1周血清HBVDNA水平,观察肝功能变化并检测血清HBeAg水平。结果:HBVDNA阳性组与HBVDNA阴性组比较,60例HBVDNA阳性HCC患者中HBeAg阳性患者为48例,阳性率为80%,60例HBVDNA阴性HCC患者中HBeAg阳性患者为12例,阳性率为20%,(P<0.05)。不同侵袭组HBeAg表达比较:32例高侵袭组中29例HBeAg检测阳性,阳性率为90.62%,28例低侵袭组中19例HBeAg检测阳性,阳性率为67.86%,(P<0.05)。结论:早期肝癌患者血清HBVDNA和HBeAg可作为肝细胞癌复发转移监测指标。Objective：To study the relationship between the expression level of HBeAg and the metastasis in hepatocarcinoma （HCC） patients after hepatectomy with expression of HBV DNA. Methods： Sixty cases of HCC with po itive HBV DNA and 60 cases with negative HBV DNA were selected,60 cases with positive HBV DNA were divided into high invasive and low invasive groups. Results：The level of HBeAg in HCC with high invasive group was significantly higher than that with low invasive group （ P 〈 0.05 ）. Conclusion ： High level of serum HBV DNA would result in the aggravation of hepatic dysfunction. Detection of the levels of serum HBeAg and serum HBV DNA can predict metastasis of HCC.

关 键 词：HBV DNA阳性 肝癌 转移 HBEAG 

分 类 号：R735.7[医药卫生—肿瘤]