^(89)SrCl_2和^(153)Sm-EDTMP治疗转移性骨肿瘤骨痛的疗效比较  

Palliating pain with ^(89)SrCl_2 and ^(153)Sm-EDTMP in multiple bone metastasis patients

作　　者：周润锁[1] 徐海峰[1] 袁梦晖[1] 孙涛[1] 周飞华[1] 

机构地区：[1]第四军医大学唐都医院核医学科,陕西西安710038

出　　处：《现代肿瘤医学》2009年第11期2215-2217,共3页Journal of Modern Oncology

摘　　要：目的:对比评价89SrCl2和153Sm-EDTMP治疗转移性骨肿瘤的临床疗效和不良反应。方法:对124例有不同程度骨痛,伴或不伴有活动受限的广泛转移性骨肿瘤患者分成二组,40例应用89SrCl2(89Sr组)治疗,84例用153Sm-EDTMP(153Sm组)治疗。结果:89SrCl2和153Sm-EDTMP对骨痛止痛总有效率分别为80%和78.6%,差异无显著性,但前者的病灶变化例数明显高于后者。结论:对经济条件好,存活时间较长。Objective：To evaluate the effect of pallating bone pain with ^89 SrCl2 and ^153 Sm -EDTMP in bone metastasis patients. Methods： In 124 cancer patients with painful limitation of movement due to bony metastasis were divided into two groups ：40 patients were treated by ^89SrCl2 （group ^89Sr ） and 80 patients were treated by ^153 Sm - EDTMP（group ^153Sm）. Results： The remission rates of bone pain were 80% and 78.6% in group ^89Sr and group ^153Sm（ P 〉 0.05 ） ,but time of bone pain relife was much longer,metastaic foci in bone became smaller or even disppeared gradually after the administration of ^89SRCl2. Conclusion： Good financial eondition,survivae time was much longer and inconvenient hospitalization patients with multiple bone matastasis should select ^89SRCl2. It may be the better choice for multiple bone matastasis.

关 键 词：骨转移癌 放射疗法 89SrCl2 153SM-EDTMP 

分 类 号：R738.1[医药卫生—肿瘤]