HLA-A等位基因及超型与宫颈癌易感性的关联  

Relationship among HLA-A alleles,supertype and the susceptibility of cervical cancer

作　　者：邱小萍[1] 陶宁[2] 谭云[1] 伍欣星[1] 

机构地区：[1]武汉大学医学部病毒所分子病毒室,湖北武汉430071 [2]武汉大学公共卫生学院,湖北武汉430071

出　　处：《基础医学与临床》2009年第11期1161-1165,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(30772308;30872935)

摘　　要：目的研究湖北土家族HLA-A等位基因及超型与HPV感染、宫颈癌的关联。方法在居住地及年龄相匹配的条件下,HPV感染阳性的癌症组分别与HPV感染阳性的对照组和HPV感染阴性的对照组进行比较。癌症组100例(其中HPV感染阳性者86例),对照组187例(其中HPV感染阳性者95例,HPV感染阴性者92例)。采用SBT法对最具多态性的HLA-A位点的2、3外显子进行基因型分析。结果HPV阳性宫颈癌组与HPV阳性对照组比较,超型HLA-A3(Pcorrected=0.015,OR=2.01,95%CI=1.26～3.21)可增加宫颈癌的易感性。HPV阳性宫颈癌组与HPV阴性对照组比较,HLA-A*0206(Pcorrected=0.025,OR=0.20,95%CI=0.07～0.58)超型HLA-A2(Pcorrected=0.005,OR=0.57,95%CI=0.37～0.88)可降低宫颈癌的易感性,而超型HLA-A3(Pcorrected=0.005,OR=2.36,95%CI=1.45～3.85)同样增加宫颈癌的易感性。结论超型HLA-A3为宫颈癌的风险因子。Objective To study the relationship among HLA-A alleles, supertype, HPV infection and cervical cancer in Tu Nationality of Hubei province. Methods As a case-control surevy. The comparisons included the comparison between HPV positive cases and HPV positive women in control group, and the comparison between HPV positive cases and HPV negative women in control group. Number of cases was 100 （ HPV positive in 86 ） , and control was 187 （HPV positive in 95 and HPV negative in 92）. The most polymorphism of 2 and 3 exons of the HLA-A alleles were analyzed by the high-resolution typing method-sequence-based typing（SBT）. Results Comparison between HPV positive cases and HPV positive control women. Supertype HLA-A3 （P corrected= 0. 005, OR = 2. 36, 95% CI = 1.45 -3.85 ） was risk factors. Comparison between HPV positive cases and HPV negative control women, HLA-A ＊ 0206 alleles （P corrected =0. 025 ,OR =0. 20,95% CI =0. 07 -0. 58）supertype HLA-A2 （P corrected = 0. 005 , OR = 0.57,95% CI = 0. 37 - 0. 88 ） was protective factor . Supertype HLA-A3 （ P corrected= 0. 005 , OR =2.36, 95% CI = 1. 45 - 3.85） was also related to the susceptibility of cervical carcinoma. Conclusion Supertype HLA-A3 is a risk factor of cervical cancer.

关 键 词：宫颈癌 人乳头瘤病毒 人类组织相容性抗原 SBT 

分 类 号：R737.33[医药卫生—肿瘤]