眼老化过程中的视网膜成像特征  

Effect of aging on retinal image characteristics of the human eye's point spread function

作　　者：黄芳[1] 马蓉[1] 宋慧洋[1] 

机构地区：[1]温州医学院附属眼视光医院,浙江温州325027

出　　处：《眼视光学杂志》2009年第5期357-359,363,共4页Chinese Journal of Optometry & Ophthalmology

摘　　要：目的通过点扩散函数分析系统,研究不同年龄段正常人眼视网膜成像质量的表达特征。方法按入选标准将健康人83例(103只健康眼)纳入到本实验中。研究对象年龄为18～87岁,平均(49.1±21.3)岁,等效球镜范围+0.75～-2.25D,散光范围为0.25～1.00D,裸眼或矫正视力均≥4.9。按年龄分成3组:40岁以下组29例(43眼),41～65岁组26例(27眼),66岁以上组28例(33眼)。在标准条件下使用PSF-1000分析仪进行3mm和5mm入瞳的视网膜像质检测,并得出调制传递函数(modulation transfer function,MTF)数据。实验结果采用SPSS13.0进行统计学分析。结果①在3mm和5mm入瞳时,40岁以下组的各空间频率的MTF值水平最高,66岁以上组最低,差异具有显著性(P=0.000);随空间频率增加,各年龄组的MTF值逐渐下降,差异具有显著性(P均<0.01)。②3mm入瞳的各空间频率MTF值均高于5mm入瞳,差异均有显著统计学意义(P均<0.01)。结论随着年龄的增加,视网膜成像质量在逐渐下降;在晚间瞳孔散大的情况下,视网膜像质会进一步下降,尤其在老年时会更加明显。Objective To analyze the retinal image characteristics of healthy persons at different ages using the point spread function（PSF） analysis system.Methods Eighty-three normal subjects（103 eyes） aged from 18 to 87 years [mean（49.1±21.3）years] were included in the study and divided into three age groups：≤40 years,41～65 years and ≥66 years.MTF data from a PSF-1000 analyzer under small pupil（3 mm） and dilated pupil（5 mm） conditions were collected and compared.Results The MTF was significantly different when the three groups were compared at all spatial frequencies under small and dilated pupil conditions（P〈0.01）.The younger subjects had significantly higher MTF measurements compared to the elderly subjects at all spatial frequencies under small and dilated pupil conditions（P=0.000）.The MTF decreased with an increase in spatial frequency in all three age groups（P〈0.01）.The MTF was also significantly different between small pupil and dilated pupil conditions（P〈0.01）.MTF measurements were significantly higher under small pupil（3 mm） conditions compared to dilated pupil conditions at all spatial frequencies（P〈0.01）.Conclusion Retinal image quality declines with aging.It further declines under dilated pupil conditions at night,especially in the elderly.

关 键 词：视网膜成像 点扩散函数 调制传递函数 

分 类 号：R770.424[医药卫生—眼科]