补肾壮阳胶囊对抑郁模型大鼠行为学的影响  

Effects of Warm-Supplementing Kindey-Yang Capsules on Behavior of Depression Model Rats

作　　者：陈振华[1] 黄永兰[1] 陈继红[2] 王高华[1] 

机构地区：[1]武汉大学人民医院精神卫生中心,湖北武汉430060 [2]武汉大学人民医院消化内科,湖北武汉430060

出　　处：《武汉大学学报（医学版）》2009年第6期752-755,共4页Medical Journal of Wuhan University

基　　金：美国Stanley基金资助项目(编号:TS200301)

摘　　要：目的:评价补肾壮阳胶囊对抑郁模型大鼠行为学的影响。方法:连续21d慢性轻度不可预见性应激配合孤养方法建立大鼠抑郁模型。40只雄性SD大鼠,随机分为正常对照组、抑郁模型组、氟西汀+抑郁模型组和补肾壮阳胶囊+抑郁模型组。观测实验过程中各组大鼠的旷场试验、体重、摄食量、糖水消耗试验和情绪性行为评分的变化。结果:模型组大鼠的水平穿越格数、垂直运动次数、理毛时间均减少,中央格停留时间、粪便粒数均增加;体重增长量、糖水消耗量均明显减少,情绪性行为评分降低,与正常对照组相比,差异具有显著性(P<0.05)。补肾壮阳组大鼠的水平穿越格数、垂直运动次数、理毛时间均有增加,中央格停留时间、粪便粒数均有减少,差异具有显著性;体重增长量、糖水消耗量均明显增加,情绪性行为积分升高,与模型组相比,差异具有显著性(P<0.05);与氟西汀组相比差异无显著性。结论:补肾壮阳胶囊具有抗抑郁的功能。Objective：To investigate the effects of Warm-Supplementing Kindey-Yang （WSKY） capsule,a traditional Chinese medicine,on the behavior of depression model rats. Methods：The chronic stressed depression rats were established by chronic unpredictable mild stress and separation for 21 days. Forty SD male rats were randomly divided into four groups including normal control group,depression model group,fluoxetine＋depression model group,and WSKY＋ depression model group. The behaviors of rats were evaluated by open-field test,body weight,the consumption of saccharose,and emotional behavior test. Results：Compared with normal control group,body weight and consumption of saccharose of rats in depression model group decreased remarkably and square crossing,rears and grooming frequency reduced while central stopped increased in open-field test （all P〈0.05）. On the 22nd day of WSKY treatment,all the records of the behavior testing of WSKY group were significantly ameliorated （all P〈0.05） when compared with those in depression model group,while there were no significant difference when compared with fluoxetine group. Conclusion：WSKY has antidepression effects on depression model rats.

关 键 词：补肾壮阳 抑郁模型 盐酸氟西汀 

分 类 号：R749.053[医药卫生—神经病学与精神病学]