肿瘤药敏试验指导个体化治疗的研究进展  

Progress of individualized chemotherapy guided by chemosensitivity test

作　　者：米彦军[1] 张传钊[1] 符立梧[1] 

机构地区：[1]中山大学肿瘤防治中心华南肿瘤学国家重点实验室,广东广州510060

出　　处：《药学学报》2009年第11期1187-1192,共6页Acta Pharmaceutica Sinica

基　　金：广州市科技攻关项目(2007Z3-E4121)

摘　　要：肿瘤患者对化疗的反应不尽相同,为了实现化疗的个体化、提高化疗的疗效,肿瘤药敏试验已逐渐在研究所和医院中开展。肿瘤药敏试验有助于为患者选择有效的化疗药物和制定合理的治疗方案,并能排除无效药,实现化疗药物(方案)个体化。目前,肿瘤药敏试验已发展为体内和体外两大系列10多种药敏试验,包括分离肿瘤单细胞体外培养法(MTT、MTS、ATP等不同检测方法)、裸鼠移植瘤模型法、胶原凝胶包埋培养法和微组织块培养法等。本文将就肿瘤药敏试验的常用方法、与临床结果的相关性研究、待解决的问题及应用前景等方面进行综述。In spite of receiving chemotherapy, the response of patients with cancer can be extremely variable. Chemosensitivity testing is being applied in institutes and some hospitals to improve the effects of chemotherapy. It would be useful for choosing the most effective drug and strategy for individual chemotherapy and to exclude the resistance of the tumor cells. In this way, the individualized chemotherapy can be established. Up to today, there are more than 10 approaches established for chemosensitivity testing assays, such as single cell culture assay （including MTT, MTS, ATP）, nude mouse model sensitivity examination, collagen gel droplet embedded culture drug sensitivity test and histoculture drug response assay etc. This paper reviews some current methods, and their possibility for directing clinical chemotherapy.

关 键 词：肿瘤 药敏试验 个体化治疗 

分 类 号：R730.5[医药卫生—肿瘤]