炎症性肠病血管累及机制的研究进展  

Progress in Study of Vascular Involvement in Inflammatory Bowel Disease

作　　者：顾嫣[1] 冉志华[1] 

机构地区：[1]上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所,200001

出　　处：《胃肠病学》2009年第10期630-632,共3页Chinese Journal of Gastroenterology

摘　　要：炎症性肠病(IBD)是一种侵及胃肠道的特发性炎症反应,其发病机制尚不十分清楚。血管生理异常可能在IBD发生和长期持续存在的过程中起多方面的作用。微循环及其内皮连接通过严密调控白细胞的迁移来维持黏膜免疫的内环境稳定。微血管内皮在白细胞募集、调节固有免疫、促血小板活化、促凝血活性和血管再生中有一定的作用。此外,IBD中亦存在大血管异常。本文就IBD血管累及机制的研究进展作一综述。Inflammatory bowel disease （IBD） is an idiopathic inflammatory disorder involved in gastrointestinal tract, and its etiology is still not fully clear. The vascular abnormality may play a role in the initiation and perpetuation of IBD. Microcirculation and its vascular endothelium maintain the mucosal immune homeostasis via regulating the migration of leukoeytes. Microvascular endothelium plays a role in the recruitment of leukocytes, modulation of innate immunity, activation of platelet, hypercoagulability and the angiogenesis. In addition, abnormality of great vessels is also found in IBD. This article reviewed the progress in the study of vascular involvement in IBD.

关 键 词：炎症性肠病 细胞黏附 微血管 血栓形成 

分 类 号：R574[医药卫生—消化系统]