鼻咽癌中B7-H3的表达及其临床意义  

Expression of B7-H3 in nasopharyngeal non-keratinizing carcinoma and its clinical significance

作　　者：汪春福[1] 邹桂华[1] 邓院萍 温寿清 

机构地区：[1]深圳市宝安人民医院,广州深圳518101

出　　处：《现代肿瘤医学》2009年第12期2290-2292,共3页Journal of Modern Oncology

基　　金：深圳市宝安区科技计划资助(2006004)

摘　　要：目的:研究鼻咽癌中T淋巴细胞共刺激分子B7-H3表达与临床病理因素的相关性。方法:采用免疫组化SP法检测B7-H3在56例鼻咽癌标本中的表达情况,分析其与肿瘤类型,大小,淋巴结转移情况的关系。结果:在鼻咽非角化型分化性癌和鼻咽非角化型未分化性癌中B7-H3阳性表达率差别无统计学意义(P>0.05),有颈部淋巴结转移和无颈部淋巴结转移的鼻咽癌标本中B7-H3的阳性表达率差别有统计学意义(P<0.05)。结论:B7-H3的表达可能与鼻咽癌的转移和进展有关,与鼻咽癌组织学类型无关。Objective ：To study the expression of B7 -H3 in nasopharyngeal non -keratinizing carcinoma and its relation with clincopathological variables. Methods： The expression of B7 - H3 in 56 surgically resected specimens of nasopharyngeal non - keratinizing carcinoma was evaluated immunohistochemically. The correlation between B7 - H3 expression and clincopathlogical variables was analyzed. Results： There was no significant difference between patients with differential nasopharyngeal non - keratinizing carcinoma and those with nondifferential nasopharyngeal non - keratinizing carcinoma in positive expression of B7 - H3 （ P 〉 0. 05 ）, and there was a significant association be- tween the high expression for B7 -H3 and lymph node metastasis（ P 〈 0.05 ）. Conclusion： The expression of 137 - H3 is probably related to the metastasis and development of nasopharyngeal carcinoma.

关 键 词：鼻咽癌 免疫组织化学 B7-H3 

分 类 号：R739.63[医药卫生—肿瘤]