乳腺癌组织内NF-κB p65的表达与淋巴转移的关系  

Relationship between NF-κB expression and lymphatic metastasis in breast cancer

作　　者：孙平[1] 王羽[1] 李明秋[1] 刘跃光[1] 滕诚毅[1] 冯克俭[1] 

机构地区：[1]牡丹江医学院解剖教研室,黑龙江牡丹江157011

出　　处：《现代肿瘤医学》2009年第12期2304-2307,共4页Journal of Modern Oncology

基　　金：黑龙江省卫生厅科研项目(2007-015);牡丹江医学院科研项目(B200816)

摘　　要：目的:研究乳腺癌组织内细胞核因子(NF-κBp65)与血管内皮生长因子-C(VEGF-C)的表达及意义。方法:采用SABC免疫组化染色法检测乳腺癌组织及癌旁对照组织内NF-κBp65与VEGF-C蛋白的表达,并分析二者的相关性及与临床病理因素的关系。结果:乳腺癌组织内NF-κBp65蛋白表达的阳性率为76.0%,明显高于癌旁对照组织30.0%(P<0.05);乳腺癌组织内VEGF-C蛋白表达的阳性率为84.0%,明显高于癌旁对照组织20.0%(P<0.05);乳腺癌组织内NF-κBp65蛋白与VEGF-C蛋白的表达呈正相关(γ=0.53,P<0.05),并且均与肿瘤淋巴转移密切相关。结论:乳腺癌组织内NF-κBp65的高表达可上调VEGF-C表达,进而导致肿瘤周围淋巴管增生、扩张,促进肿瘤细胞向区域淋巴结转移。Objective：To study the expression and significance of NF - κB p65 and VEGF - C in breast cancer. Methods： Expression of NF - κB p65 and VEGF - C in breast cancer and normal tissue were detected by SABC immunohistochemical staining method and relationship of their expressions with clinical factors was analyzed. Results： 76% of NF - κB p65 in breast cancer was significantly higher than 30.0% in normal tissue（P 〈0.05） ;84.0% of VEGF - C in breast cancer was also significantly higher than 20.0% in controls（P 〈 0. 05 ） ; Significant positive relationship was found between NF - κB p65 and VEGF - C （ r = 0.53, P 〈 0.05 ） and their expression was closely related with lymphatic metastasis of tumor. Conclusion： NF - κB 1965 can up - regulate VEGF - C expression in breast cancer, resulting in lymphangiogenesis and distension in the periphery of tumor, and then enhance tumor cells metastasize to the regional lymph nodes.

关 键 词：NF—κB P65 VEGF—C 乳腺癌 淋巴转移 

分 类 号：R737.9[医药卫生—肿瘤]