恩度联合卡培他滨治疗晚期胃肠道肿瘤12例临床观察  

Clinical observation of endostar combined with capecitabine to cure advanced stage gastrointestinal cancer

作　　者：钟漓[1] 张广钰[1] 

机构地区：[1]桂林医学院附属医院普通外科,广西桂林541001

出　　处：《现代肿瘤医学》2009年第12期2406-2408,共3页Journal of Modern Oncology

摘　　要：目的:探讨重组人血管内皮抑制素注射液(恩度)联合卡培他滨治疗晚期胃肠道癌的有效性和安全性。方法:经病理组织学或细胞学检查确诊的Ⅳ期患者12例,其中胃癌3例,结肠癌5例,直肠癌4例,接受恩度联合卡培他滨治疗。恩度15mg加生理盐水500ml匀速缓慢滴注1-14d,间歇7d,重复给药;卡培他滨每日2500mg/m2分早、晚2次口服,于饭后半小时用水吞服,1-14d,休息7d,21d为1周期。按照RECIST标准评价近期疗效,用药1周期评价毒性,两周期后评价疗效。结果:10例患者可评价疗效和安全性。共完成24个周期,平均2.4周期,获得CR1例、PR2例、SD5例、PD2例。客观有效率(RR)为30%,疾病控制率为80%,生活质量改善者4例、稳定4例、下降2例。毒性反应主要与化疗药物有关,手足综合症1例,腹泻1例,血清转氨酶升高2例。结论:恩度联合卡培他滨治疗晚期胃肠道癌具有协同作用,疗效好、毒性低、安全性好、可改善患者的生活质量,值得进一步研究观察。Objective：To study the efficacy and safety of endostar combined with capecitabine to cure advanced gastrointestinal cancer. Methods：Twelve cases with advanced gastroitestinal cancer diagnosed by pathohistology or cytology,including gastric cancer 3, colon cancer 5, rectum cancer 4. Endostar injection 15mg and physiological saline 500ml was injected intravenously in the first 14 days. Capecitabine（2500mg/m2, twice per day） was performed with orally administration in the first 14 days in one course of treatment （21days） . The adverse reaction was evaluated after two courses of treatment. Results：Total of 24 cycles of treatment was performed to the patieats, CR, PR, SD and PD took place in 1 case ,2 cases ,5 cases and 2 cases. The RR was 30% and the DCR was 80%. Quality of life was improved in 4 cases, no change in 4 cases and decreased in 2 cases. The adverse reaction： hand - foot syndrome took place in l patient,diarrhiea took place in 1 patient, elevated serum transaminase took place in 2 patients. Conclusion：The effect of endostar combined with eapeeitabine to cure advanced gastrointestinal cancer is good and can improve the patient＇s life quality.

关 键 词：恩度 卡培他滨 胃肠癌 抗肿瘤血管形成 

分 类 号：R730.53[医药卫生—肿瘤]