茶多酚对移居高原人群视听觉认知功能的改善作用  

Improvement of visual-auditory cognitive functions of the population immigrating high altitude by taking in tea polyphenols

作　　者：李晓莉[1,2,3,4] 蒋春华[1,2,3] 刘福玉[1,2,3] 廖卫公[1,2,3] 周其全[2,3,5] 崔建华 马勇 高钰琪[1,2,3] 

机构地区：[1]第三军医大学高原军事医学系病理生理学与高原生理学教研室,重庆400038 [2]第三军医大学高原医学教育部重点实验室,重庆400038 [3]全军高原生理与高原病研究重点实验室,重庆400038 [4]解放军军事经济学院营养食品研究所,湖北武汉430035 [5]第三军医大学高原军事医学系高原疾病学教研室,重庆400038 [6]解放军第十八医院,新疆叶城844900

出　　处：《中国药理学通报》2009年第11期1473-1476,共4页Chinese Pharmacological Bulletin

基　　金：国家重点基础研究发展计划(973计划)资助项目(No2006CB504101);"十一五"军队专项课题(No06Z037)

摘　　要：目的观察茶多酚对移居高原人群视听觉认知功能的改善作用。方法38名移居高原(海拔高度为3700m,移居时间为90d)的健康男性青年随机分为2组:①对照组(安慰剂,40mg/d,30d)、②茶多酚组(茶多酚,300mg/d,30d)。应用视听整合连续测试系统(integrated visual and auditory continuous performancetest,IVA-CPT)检测以上各组服用试验品前后的认知功能,通过前后比较评价茶多酚对移居高原人群视听觉认知功能的改善作用。结果与服用前比较,服用茶多酚后,听觉反应控制谨慎商数(auditory prudence quotient,PruA)明显升高(P<0.05);服用试验品后,茶多酚组PruA明显高于对照组(P<0.05),其余各指标组间比较差异无显著性。结论茶多酚能提高移居高原人群部分视听觉认知功能。Aim To observe the improvement of visual-auditory cognitive functions in the human entering high altitude by taking in tea polyphenols.Methods Thirty eight males living at 3 700 m high altitudes for 90 days constantly were randomly divided into two groups： ①group Ⅰ（placebo,40 mg/day）; ②group Ⅱ（TP,300 mg/day）.Cognitive functions were measured by integrated visual and auditory continuous performance test and the difference between groups was evaluated by the comparisons of post-treatment to pre-treatment.Results Compared with pre-treatment,PruA was significantly higher after taking in TP（P0.05）;after treatment,PruA in group Ⅱ was significantly higher than that in group Ⅰ（P0.05）.Conclusion Tea polyphenols can partly improve visual-auditory cognitive functions of human entering high altitude.

关 键 词：高原 缺氧 移居高原人群 认知功能 视听整合连续测试系统 茶多酚 

分 类 号：R284.1[医药卫生—中药学] R339.14[医药卫生—中医学]