原发性开角型青光眼患者视神经盘沿面积、视网膜神经纤维层厚度与分辨光敏感度之间的关系  

Correlation between Neuroretinal Rim Area/Retinal Nerve Fiber Layer Thickness and Differential Light Sensitivity in Visual Field in Primary Open Angle Glaucoma

作　　者：李略[1] 赵家良[1] 刘小力[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院眼科,北京100730

出　　处：《中国医学科学院学报》2009年第5期607-611,共5页Acta Academiae Medicinae Sinicae

摘　　要：目的评估原发性开角型青光眼患者视神经盘沿面积（RA）、视网膜神经纤维层（RNFL）厚度与分辨光敏感度（DLS）之间的关系。方法采用海德堡视网膜断层扫描仪、激光扫描偏振仪和标准自动视野计分别检测51例原发性开角型青光眼患者（随机选取每例患者1只眼,分为青光眼视野正常组31只和视野损害组20只）的视神经RA、RNFL厚度和DLS,对其在视盘总体及各个象限中的联系分别进行直线和对数曲线拟合性比较。结果对于青光眼总体,视野DLS与视神经RA或RNFL厚度在视盘总体及各个象限均具有显著相关性,两者的对数曲线回归模型拟合性明显优于直线。在青光眼视野正常组,两者的相关性表现为弱或无,相互关系呈接近水平的直线（R^2=0.01-0.26）。在青光眼视野损害组,两者的联系显著增强,呈对数曲线联系（R^2=0.15-0.84）。视神经RA和RNFL厚度具有良好的直线相关性。结论原发性开角型青光眼患者的视神经RA、RNFL厚度与DLS之间具有良好的相关性。Objective To explore the relationship between neuroretinal rim area （RA） /retinal nerve fiber layer （RNFL） thickness and differential light sensitivity （DLS） in visual field in primary open angle glaucoma （POAG）. Methods Fifty-one eyes of 51 patients with POAG were examined with HRT Ⅱ , GDx VCC, and Octopus 101 for RA, RNFL thickness, and DLS. Their correlations were evaluated with linear and logarithmic regression models globally and for individual sectors. al field DLS was significantly correlated with neuroretinal RA or tors. Logarithmic fits were significantly better than linear fits for Results In all the eonsidered patients, visu- RNFL thickness globally and in individual sec- the global data and in most sectors. In preperimetric glaucoma, such correlations were weak and linear （R^2 = 0. 01-0. 26 ）. However, in perimetric glaucoma, the correlations were much stronger and curvilinear model gave the better fit （R^2 = 0. 15-0. 84）. Neuro- retinal RA and RNFL thickness were linearly correlated. Conclusion Neuroretinal RA, RNFL thickness, and DLS in visual field were well correlated in POAG.

关 键 词：青光眼 盘沿面积 视网膜神经纤维层厚度 分辨光敏感度 

分 类 号：R775.2[医药卫生—眼科]