彩色多普勒超声表现与VEGF在甲状腺肿瘤中的表达  

Study of Color Doppler Flow Imaging and VEGF in Thyroid Tumours

作　　者：单叔煤[1] 王玉成[1] 奚克敏[1] 李彩娟[1] 

机构地区：[1]牡丹江医学院附属红旗医院,黑龙江牡丹江157011

出　　处：《医疗卫生装备》2009年第11期71-73,共3页Chinese Medical Equipment Journal

基　　金：黑龙江省卫生厅资助项目(2007-051)

摘　　要：目的:探讨彩色多普勒血流显像(CDFI)与血管内皮生长因子(VEGF)在甲状腺肿瘤中的表达。方法:应用免疫组化SP法检测90例甲状腺肿瘤组织中VEGF表达情况及采用彩色多普勒检测宏观血流情况。结果:VEGF在甲状腺癌组织中的阳性表达率(73.8%)明显高于甲状腺腺瘤组织(24.0%),差异有显著性(P<0.01)。VEGF在甲状腺滤泡状癌和甲状腺乳头状癌中的表达差异有显著性。CDFI显示甲状腺腺瘤与甲状腺癌的血管结构之间差异有显著性;甲状腺乳头状癌与甲状腺滤泡状癌之间差异无显著性。结论:VEGF可作为判断甲状腺肿瘤生物学行为的有用指标。CDFI在甲状腺肿瘤的诊断中具有明显应用价值。Objective To investigate the expression of vascular endothelial growth factor（VEGF） and Color Doppler flow imaging in human thyroid tumours. Methods 90 cases of thyroid tumours were examined for VEGF expression by means of immunohistochemistry and were examined with color Doppler ultrasound for blood flow. Results The positive rates of VEGF expression were much higher in thyroid carcinomas than that in thyroid adenomas. The difference was significant（ P0.01 ）. The express of VEGF in Papillary thyroid cancer and Follicular thyroid cancer had evident difference. CDFI showed that the difference of blood supply is significant. But the displayed rate of blood flow in CDFI between malignant thyroid tumors and benign thyroid tumors had no obvious difference. Conclusion The expressions VEGF in thyroid tumour could be used as an important biologic marker for thyroid tumour. Color Doppler flow imaging played a very important role in the diagnosis of thyroid tumour.

关 键 词：甲状腺肿瘤 彩色多普勒血流显像 血管内皮生长因子 

分 类 号：R736.1[医药卫生—肿瘤]