柯萨奇和腺病毒受体在非小细胞肺癌组织中的表达及意义  

Expression of coxsackie and adenovirus receptor and its significance in non-small cell lung cancer

作　　者：王仕忠[1] 马玲娣[1] 关乃富[2] 鲍永仪[2] 倪诚[3] 王勇 

机构地区：[1]南京医科大学附属常州第二人民医院中心实验室,常州213003 [2]南京医科大学附属常州第二人民医院病理科,常州213003 [3]南京医科大学附属常州第二人民医院科教科,常州213003 [4]南京医科大学附属常州第二人民医院心胸外科,常州213003

出　　处：《临床与实验病理学杂志》2009年第5期481-484,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：江苏省社会发展资助项目(NoBS2007025);常州市社会发展项目(NoCS2007216)

摘　　要：目的研究柯萨奇和腺病毒受体（coxsackie and adenovirus receptor,CAR）在非小细胞肺癌组织中的表达及意义。方法用特异性CAR72抗体通过免疫组化EnVision法在存档石蜡样本中研究CAR在非小细胞肺癌组织中的表达。结果14例非肿瘤肺组织全部无CAR表达,51例鳞癌中42例有CAR表达,不同病理分级肺癌细胞中（5例穿刺标本未作病理分级）,CAR表达分别为分化好（Ⅰ-Ⅱ级）有20例（20/26）表达,分化差（Ⅲ-Ⅳ级）有17例（17/20）表达。在41例肺腺癌中仅有15例有CAR表达,不同病理分级肺癌细胞中（3例穿刺标本未作病理分级）,CAR表达分别为分化好（Ⅰ-Ⅱ级）有8例（8/21）表达,分化差（Ⅲ-Ⅳ级）有6例（6/17）表达。结论CAR表达与非小细胞肺癌发生的组织类型相关而与细胞分化程度无关。Purpose To investigate the expression of coxsackie and adenovirus receptor（CAR） in non-small cell lung cancer（NSCLC） tissues.Methods Specific CAR72 antibody was used to show the expression of CAR in NSCLC paraffin-embedded tissue samples by immunohistochemistry.Results CAR expression was found in squamous cell carcinoma（42/51） and adenocarcinoma（15/41） but not found in normal lung（0/14）.In squamous cell carcinoma,Expression of CAR in well-differentiated and poorly-differentiated carcinoma were all 20,and no statistical difference was observed.In lung adenocarcinoma,there were 8 cases of well-differentiated adenocarcinoma and 6 cases of poorly-differentiated carcinoma respectively and no statistical difference was also observed.Conclusions The expression of CAR is related to the histological type,but unrelated to differentiation in NSCLC.

关 键 词：肺肿瘤 CAR非小细胞肺癌 分化 组织学类型 

分 类 号：R734.2[医药卫生—肿瘤]