副脊索瘤3例报道并文献复习  

Parachordoma:a report of 4 cases and review of literature

作　　者：牛多山[1] 杨杰[1] 陈海玲[1] 葛霞[2] 

机构地区：[1]安徽省宣城市人民医院病理科,宣城242000 [2]蚌埠医学院病理学教研室,蚌埠233030

出　　处：《临床与实验病理学杂志》2009年第5期491-493,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨副脊索瘤临床病理学特点及其诊断与鉴别诊断。方法对报道的3例副脊索瘤进行临床资料分析、组织学形态和免疫表型观察并复习相关文献。结果副脊索瘤好发于四肢深部软组织。大体呈分叶状或多结节状,瘤细胞圆形或多边形,呈条索状或小巢状排列,胞质内含有空泡,间质富有黏液基质。免疫组化标记:CAM 5.2、EMA、S-100、SMA、ColⅣ阳性表达,CEA、CK19、Des阴性。结论副脊索瘤是一种少见的软组织肿瘤,组织学形态特点是其诊断的主要依据,免疫组化标记有助于诊断和鉴别。Purpose To investigate the clinicopathological feature,diagnosis and differential diagnosis of parachordoma.Methods Three cases of parachordoma were studied by clinical data analyses,histopathology and immunohistochemistry.The related literature were reviewed.Results The tumors mainly occurred in the deep soft tissue of the limbs.Tumor was lobulated or multinodular.The neoplastic cells were round or polygon with vacuoles within the cytoplasma which arranged in nests or cords,and the stroma was rich in myxoid matrix.Immunohistochemically,the tumor cells were positive for CAM 5.2,EMA,S-100,SMA,collagen Ⅳ,and negative for CEA,CK19 and desmin.Conclusions Parachordoma is a rare soft tissue tumor,and its diagnosis mainly depends on histopathologic feature.Immunohistochemistry is helpful for the diagnosis and differential diagnosis.

关 键 词：副脊索瘤 诊断 鉴别诊断 免疫组织化学 

分 类 号：R730.262[医药卫生—肿瘤]