肺鳞癌和肺腺癌胸内淋巴结转移相关因素分析  

Analysis of Risk Factors for Lymph Node Metastasis in Thoracic Cavity of Squamous Cell Lung Cancer and Adenocarcinoma

作　　者：马军亮[1] 刘伦旭[1] 蒲强[1] 朱云柯[1] 

机构地区：[1]四川大学华西医院胸心外科,成都市610041

出　　处：《中国肿瘤临床》2009年第20期1156-1159,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:分析肺鳞癌和腺癌胸内淋巴转移的相关危险因素,为临床的分析判断提供依据。方法:对2006年6月至2008年6月本院行手术治疗140例肺鳞癌和腺癌患者的临床资料作回顾性分析。通过单因素x^2检验及多因素非条件Logistic回归统计分析,分析患者的性别、年龄、术前病程、肿瘤位置、肿瘤大小、病理类型、细胞分化程度、有无局部侵犯和T分期等相关因素与胸内淋巴结转移的相关关系。结果:在单因素分析中,胸内淋巴结转移与性别,肿瘤的位置、大小、细胞分化程度、局部侵犯、T分期有统计学意义(P<0.05),而在T分期中,T_1和T_2,T_3,T_4之间均有统计学意义(P<0.001)。在胸内淋巴结转移率中,男性(57.7%)>女性(36.1%);中央型肺癌(65.3%)>周围型肺癌(45.1%);直径>3cm肿瘤(62.8%)直径≤3cm的肿瘤(35.2%);中分化以下的(59.8%)>中分化及以上的(37.5%);有外侵肿瘤(77.3%)大于没有外侵的肿瘤(47.5%);pT_4>pT_3>pT_2>pT_1(82.4%>66.6%>60%>20%)。而在多因素分析中,胸内淋巴结转移与T分期、肿瘤大小、局部外侵具有统计学意义(P<0.05)。结论:T分期、肿瘤大小、局部外侵是肺鳞癌及腺癌胸内淋巴结转移的危险因素。Objective： To investigate the risk factors for mous cell lung cancer and adenocarcinoma and to provide lymph node metastasis in thoracic cavity of squareference for clinical analysis. Methods： A total of 140 cases of squamous cell lung cancer and adenocarcinoma seen in our hospital between June 2006 and June 2008 were retrospectively analyzed. The probable risk factors including sex, age, course, tumor localization, tumor size, histology, pathological differentiation, local invasion and T status were collected and analyzed with chi-square test and Logistic regression. Results： In the single factor analysis, the presence of lymph node metastasis in thoracic cavity was correlated with sex, tumor location, tumor size, pathological differentiation, local invasion and T status （P〈0.05）. For T status, there was significance among patients of pT1, pT2, pT3 and pT4 （P〈0.001）. The rate of lymph node metastasis was higher in male patients （57.7%） than in female patients （36.1%）. The rate of central lung cancer （65.3%） was higher than that of peripheral lung cancer （45.1%）. The rate of lung cancer with tumor diameter 〉3 cm （62.8%） was higher than that of lung cancer with tumor diameter ≤3 cm （35.2%）. The rate of poorly-differentiated lung cancer （59.8%） was higher than that of moderately-differentiated and well-differentiated Jung cancer （37.5%）. The rate of lung cancer with local invasion （77.3%） was higher than that of lung cancer without local invasion （47.5%）. pT4〉pT3〉pT2〉pT1 （82.4%〉66.6%〉60%〉20%）. However, Logistic regression analysis showed that the lymph node metastasis in thoracic cavity was significantly corretated with T status, tumor size and local invasion （P〈0.05）. Conclusion： T status, tumor size and local invasion are risk factors for lymph node metastasis in thoracic cavity of squamous cell lung cancer and adenocarcinoma.

关 键 词：肿瘤 淋巴结转移 LOGISTIC回归 

分 类 号：R734.2[医药卫生—肿瘤]