上海地区女性外阴尖锐湿疣患者宫颈HPV感染及分型研究  

Cervical human papiUomavirus （HPV） infection and associated genotypes in female patients with vulvar condyloma acuminatum from Shanghai area

作　　者：王秀丽[1] 王宏伟[1] 杨连娟[1] 肖芹[1] 吕婷[1] 

机构地区：[1]上海市皮肤病性病医院,200050

出　　处：《中华皮肤科杂志》2009年第11期739-741,共3页Chinese Journal of Dermatology

基　　金：国家人事部“留学人员科技活动择优资助”项目[中人厅发（2007）107号文]

摘　　要：目的探讨上海地区女性外阴尖锐湿疣患者的宫颈HPV感染情况。方法采用美国FDA批准的捕获杂交试验和基因芯片技术对194例女性外阴尖锐湿疣患者皮损和宫颈脱落细胞进行HPV基因型别研究。结果194例女性尖锐湿疣患者外阴皮损HPV检出率为100％，其中低危型HPV144例占74．2％，高危型HPV50例占25．8％。低危型中136例为单一型别感染，占94．4％，均为HPV6或HPV11；高危型中43例为低危与高危型HPV混合感染，占86％。194例患者中，166例（85．6％）合并宫颈HPV感染，其中低危型感染者119例，感染率为61．4％，高危型感染46例，感染率为23．7％。外阴和宫颈皮损HPV型别的一致性达到95．8％（159／166），低危型HPV感染率从高到低依次为HPV11〉HPV6〉HPV53，高危型依次为HPV16〉HPV18〉HPV52〉HPV3t〉HPV45、HPV58。结论上海地区女性外阴尖锐湿疣患者中高危型HPV感染率较高，且近1／4患者合并宫颈高危型HPV感染。Objective To study cervical HPV infection in female patients with vulvar condyloma acuminatam （CA） from Shanghai area. Methods Exfoliated cells were obtained from cervices and vulva lesions of CA of 194 patients, respectively. HPV genotyping was carried out in cell samples using capture-hybridization method and gene chip techniques. Results HPV was detected in vulva lesions of all the 194 patients. Among them, 74.2% （144/194） were positive for low risk （LR）-HPV, and 25.8% （50/194） for high risk （HR）-HPV. A single HPV genotype （6 or 11 ） was detected in 136 （94.4%） patients with LR-HPV, and mixed genotypes of LR-HPV and HR-HPV in 46 （86%） patients with HR-HPV. Of the 194 patients, 85.6% （166/194） were complicated by cervical HPV infection, including 119 （61.4%） cases of LR-HPV and 46 （23.7%） cases of HR-HPV. In the case of HPV genotype, the consistence between CA lesions and cervix was 95.8% （159/166）. The prevalence of LR-HPV declined sequentially from subtype 11 to 6 and 53, and that of HR-HPV from subtype 16 to 18 followed by 52, 31, 45 and 58. Conclusions There is a high rate of infection with HR-HPV in female patients with CA, and nearly one quarter of these patients are complicated by cervical HR-HPV infection.

关 键 词：尖锐湿疣 宫颈肿瘤 人乳头瘤病毒 

分 类 号：R737.33[医药卫生—肿瘤]