脑出血患者血清S-100β蛋白与神经元特异性烯醇化酶的检测及意义  

The detection of S-100β protein and NSE in patients with cerebral hemorrhage and its significance

作　　者：王蕾 

机构地区：[1]河南信阳市中心医院神经内科,信阳464000

出　　处：《中国实用神经疾病杂志》2009年第21期15-17,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨脑出血患者血清S-100β蛋白与神经元烯醇化酶(NSE)的表达水平及与临床预后的关系。方法采用酶联免疫吸附法对36例脑出血患者起病第1、3、5天血清S-100β蛋白与NSE水平进行了动态测定。结果脑出血患者血清S-100β蛋白与NSE浓度在起病第1、3、5天均显著高于对照组(P<0.01),其表达水平的高低与临床预后有显著相关性。结论血清S-100β蛋白与NSE水平测定对判断脑出血病变的严重度、评估预后有重要参考价值。Objective To study the expression of serum S-100β protein and neuron specific enolase（NSE） explore the relationship between the expression and prognosis of patients with cerebral hemorrhage. Methods The serum S-100β protein and NSE of 36 patients with cerebral hemorrhage was tested with ELISA at 1st, 3rd and 5th day after the hemorrhage happened. Results The serum S-100β protein and NSE values at 1st, 3rd and 5th day after the hemorrhage occurred were higher than that of control group （P〈0. 01）. The expression levels of S-100β protein and NSE were significantly correlated with prognosis.Conclusion The serum S-100β protein and NSE test in patients with cerebral hemorrhage are very useful in judging the severity of the disease and the prognosis of the patients.

关 键 词：脑出血 S-100Β蛋白 神经元烯醇化酶 预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学]