肝硬化患者血清一氧化氮水平与脂质过氧化损伤的关系  

The Level of Serum Nitric Oxide and the Relation with Lipid Peroxidation in Patients with Cirrhosis of the Liver

作　　者：黄永辉[1,2] 周力[1,2] 张晓蕾 唐筑灵[1,2] 

机构地区：[1]贵阳医学院附院内科 [2]贵阳医学院老年病研究所

出　　处：《贵阳医学院学报》1998年第4期322-323,326,共3页Journal of Guiyang Medical College

摘　　要：对３９例肝硬化患者血清一氧化氮（ＮＯ）、丙二醛（ＭＤＡ）及还原型谷胱甘肽（ＧＳＨ）进行了测定，并分析其间的关系。结果表明：血清ＮＯ、ＭＤＡ水平均显示出失代偿期＞代偿期＞正常对照；血清ＧＳＨ水平显示出失代偿期＜代偿期＜正常对照。３９例患者血清ＮＯ与ＭＤＡ呈明显正相关，ＮＯ与ＧＳＨ呈明显负相关，而肝硬化患者血清ＮＯ水平与Ｃｈｉｌｄ－Ｐｕｇｈ积分呈显著负相关。可见，肝硬化患者血清ＮＯ和ＭＤＡ水平增高，ＧＳＨ水平降低。ＮＯ过量生成参与了脂质过氧化肝损伤过程。The level of serum nitric oxide (NO), malondialdehyde(MDA)and glutathione (GSH)were determined in 39 patients with cirrhosis of the liver and 22 normal subjects. The level of serum NO and MDA showed: decompensated patients>compensated patients>normal subjects, the level of serum GSH showed: decompensated patients<compensated patients <normal subjects. NO levels were correlated positively with MDA levels, and correlated negatively with GSH levels in 39 patients with cirrhosis of the liver. A strong positive correlation was also found between NO levels and Child-Pugh scores in 39 patients. The study indicated that the level of serum NO and MDA ascended in patients with cirrhosis of the liver, that of GSH descended, the increase of NO was much related to the liver damage of lipid peroxidation.

关 键 词：肝硬化 一氧化氮 脂质过氧化 丙二醛 

分 类 号：R575.202[医药卫生—消化系统]