抗磷脂抗体及凝血因子Ⅻ缺乏与视网膜静脉阻塞的相关研究  

The correlation of antiphospholipid antibody and factor Ⅻ deficiency in patients with retinal vein occlusion

作　　者：孙红晶[1] 李毓敏[2] 

机构地区：[1]浙江省中医院眼科,杭州310006 [2]浙江大学附属邵逸夫医院眼科,杭州310016

出　　处：《眼科研究》2009年第11期1019-1022,共4页Chinese Ophthalmic Research

摘　　要：目的观察抗磷脂抗体(APA)及凝血因子Ⅻ(FⅫ)缺乏在视网膜静脉阻塞(RVO)发病中的作用。方法对RVO患者33例(33眼)及正常对照组30例(30眼),采用ELISA法检测抗心磷脂抗体(ACA)(IgG、IgM、IgA);APTT法检测LA;一期法测定FⅫ活性。采用Fisher检验进行统计学分析。结果RVO组APAs总阳性率24.24%(8/33)与对照组6.67%(2/30)比较差异无统计学意义(P=0.085)。RVO组ACA阳性率18.18%(6/33)与对照组(0/30)比较差异有统计学意义(P=0.025)。≤50岁组及>50岁组RVO患者LA总阳性率与同年龄对照组相比差异均无统计学意义(P=0.160,P=0.206)。RVO组FⅫ缺乏率42.42%(14/33)与对照组13.33%(4/30)比较差异有统计学意义(P=0.013)。≤50岁组及>50岁组RVO患者FⅫ缺乏与同年龄对照组比较差异无统计学意义(P=0.206,P=0.052)。结论研究表明ACA阳性及FⅫ缺乏引起的凝血障碍与RVO发病相关。Objective Antiphospholipid antibody and factor Ⅻ deficiency are among the coagulation disorders that have been implicated in many thrombembolic events. The aim of this study was to investigate the prevalence of antiphospholipid antibodies and factorⅫ deficiency in patients with retinal vein occlusion （RVO）. Methods The investigation was a case control study. The periphery blood was collected from a cohort of 33 consecutive patients with RVO and 30 age- and gendermatched normal subjects. Anticardiolipin antibody （ACA） was detected by ELISA as binding index（BI） = A value/standard A value. The lupus anticoagulant antibody was examined by APTT test and the activity of factor Ⅻ was detected. This study was approved by The Human Research Ethics Committee of this hospital, and written informed consent was obtained from all the subjects before initiation of any study protocol. Results The total positive rate of APA in RVO group was 24.24% （8/33） , showing a insignificant difference in comparison with control group （6.67%, 2/30） （P = 0. 085 ）. The positive rate of anticardiolipin antibody in RVO group was 18.18% （6/33） ,presenting an obvious enhance in control group （P =0. 025 ）. Three patients in RVO group disclosed positive response for IgG-anticardiolipin antibody,one patient for IgM-anticardiolipin antibody, two patients for both isotypes IgG and IgM anticardiolipin antibodies, and two patients revealed positive reaction for lupus anticoagulant antibody. The presence of lupus anticoagulant antibody among the patients with ~ 50 years and 〉 50 years was similar to that in age-matched controls （P =0. 160,P =0. 206）. Factor Ⅻ deficiency was found in 14 of 33 patients（42.42% ） and in 4 of 30 controls（ 13.33% ） （P = 0. 013）. The prevalence of factor Ⅻ deficiency among the patients with ≤50 years and 〉 50 years was similar to that in age-matched controls （ P = 0. 206, P = 0. 052）. Conclusion Our results indicate that the prevalence of ACA and factor XII defi

关 键 词：视网膜静脉阻塞 抗磷脂抗体 抗心磷脂抗体 凝血因子Ⅻ缺乏 

分 类 号：R774.1[医药卫生—眼科]