EGFR和VEGF在大肠癌组织中的表达及临床意义  

Expression and significance of EGFR and VEGF in colorectal carcinoma

作　　者：魏晓莹[1] 孙新臣[2] 曹远东[2] 方明治[3] 成红艳[2] 赵迪[1] 李瑞平[1] 王国庆[1] 

机构地区：[1]东南大学附属中大医院病理科,南京210009 [2]东南大学附属中大医院肿瘤科,210009 [3]南京市中医院肿瘤科,210001

出　　处：《临床肿瘤学杂志》2009年第10期895-899,共5页Chinese Clinical Oncology

基　　金：江苏省卫生厅科研基金资助项目(H200845)

摘　　要：目的:通过免疫组化检测表皮生长因子受体(EGFR)、血管内皮生长因子(VEGF)在大肠癌(CRC)和大肠正常组织中的表达,探讨其与临床病理特征的相关性。方法:应用免疫组化En Vision法检测58例大肠癌组织(其中20例患者年龄<40岁)和癌旁正常组织28例中的EGFR和VEGF的表达水平,并结合临床资料进行统计学分析。结果:大肠癌组织中的EGFR和VEGF阳性表达率分别为43.10%和48.27%;癌旁正常组织EGFR和VEGF阳性表达率分别为7.14%和10.71%,大肠癌组织中EGFR和VEGF表达率均明显高于癌旁正常组织(P<0.01)。EGFR和VEGF的表达与大肠癌的TNM分期以及有无淋巴结转移有关(P<0.05)。EGFR和VEGF阳性表达率在年龄<40岁的大肠癌组明显高于其在年龄≥40岁的大肠癌组(P<0.05);在年龄<40岁的大肠癌组中,两者共阳性表达伴淋巴结转移率高(P<0.01)。结论:EGFR和VEGR在大肠癌组织中高表达,与大肠癌临床分期及淋巴结转移密切相关,可作为临床判断转移及预后等生物学行为的重要参考指标。年龄<40岁的早发性大肠癌具有更高的EGFR和VEGF阳性率及共表达率,提示其侵袭性更强、预后更差。Objective：To investigate the expression of epidermal growth factor receptor（EGFR） and vascular endothelial growth factor（VEGF） in colorectal carcinoma（CRC） and adjacent normal colorectal mucosa by immunohistochemical staining and explore their relationship with clinicopathological features.Methods：The expressions of EGFR and VEGF were studied by immunohistochemical En Vision staining in 58 colorectal carcinoma specimens（20 patients〈40 years of age） and 28 cases of adjacent normal tissues as control.The correlation of VEGF and EGFR expressions with the clinicopathologic parameters was analyzed statistically.Results：The positive rates of EGFR and VEGF were 43.10% and 48.27% respectively in colorectal carcinoma.However,in adjacent normal colorectal tissues,they were 7.14% and 10.71% respectively.Expressions of EGFR and VEGF proteins were significantly higher in colorectal carcinoma than those in normal tissues（P〈0.01）.In colorectal carcinoma cases,the expression of EGFR and VEGF was related to lymph node metastasis and TNM stage（P〈0.05）.In addition,higher lymph node metastasis in coexpression of EGFR and VEGF was more frequently observed in the cases with age〈40（P〈0.05）.Conclusion：The overexpression of EGFR and VEGF was closely correlated to clinical stage and lymph node metastasis in colorectal carcinoma.It might be served as an important factor for evaluating tumor biological behavior and prognosis.Presenting higher expression and coexpression of EGFR and VEGF,early-onset colorectal carcinomas show pathologic features associated with aggressive behavior and poor prognosis.

关 键 词：大肠癌 表皮生长因子受体 血管内皮生长因子 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]