1560例非小细胞肺癌患者多因素预后分析  

Prognostic factors of patients with non-small cell lung cancer:A retrospective analysis of 1560 cases

作　　者：蒋峰[1] 胡振东[1] 冯冬杰[1] 张治[1] 陆建伟[2] 史美祺[2] 冯平柏[3] 许林[1] 

机构地区：[1]江苏省肿瘤医院胸外科,南京210009 [2]江苏省肿瘤医院内科,210009 [3]江苏省肿瘤医院放疗科,210009

出　　处：《临床肿瘤学杂志》2009年第10期908-911,共4页Chinese Clinical Oncology

基　　金：江苏省社会发展重大项目基金资助课题(BS2006005);"333高层次人才培养工程"科研资助项目1210009

摘　　要：目的:综合治疗模式是提高非小细胞肺癌(NSCLC)患者生存预后的主要手段,本研究结合临床资料对1 560例大样本NSCLC预后行多因素分析,建立具有临床实用价值的预后模型,为肺癌防治提供科学依据。方法:对1998年1月1日～2004年1月1日期间我院收治的具有明确组织病理学诊断和临床分期的1 560例NSCLC患者资料,经病历查阅及严格随访,回顾性分析可能影响NSCLC患者预后的相关因素。结果:共随访1 560例NSCLC患者,失随访70例,有效病例1 490例,失访率为4.5%。Cox单因素及多因素分析表明:TNM分期、手术方式、化疗方案是否含铂类药物、KPS评分是独立的影响NSCLC患者预后的相关因素。该组病例1、3、5年生存率分别为60.6%、45.7%、25.7%。结论:TNM分期、手术方式、化疗方案是否含铂类药物、KPS评分是影响NSCLC患者的独立预后因素。Objective：To analyze the prognostic factors of non-small cell lung cancer and to find some clues for prevention and treatments of non-small cell lung cancer in the future.Methods：From January 1,1998 to January 1,2004,1 560 hospitalized non-small cell lung cancer patients with proved histology and clinical TNM stage were enrolled in our study.The factors which might affect the patients＇ prognosis were analyzed.Results：A total of 1 560 cases were enrolled in this study and 1 490 of them were followed up to the end-point of the study with 4.5%（70 cases） of loss to follow-up.Cox regression indicated that TNM stage,operative manner,application of platinum-based chemotherapy and KPS score were independent prognostic factors for patients with non-small cell lung cancer.The 1,3,5-year survival rate in our study were 60.6%,45.7%,25.7%,respectively.Conclusion：TNM stage,operative manner,application of platinum-based chemotherapy and KPS score were independent prognostic factors for patients with non-small cell lung cancer.

关 键 词：非小细胞肺癌 随访 预后 生存率 

分 类 号：R734.2[医药卫生—肿瘤]