α-MSH对内毒素性发热效应及下丘脑cAMP含量的影响  

The effect of α-MSH on ET-induced fever and hypothalamic content of cAMP in rabbits

作　　者：胡巢凤[1] 王华东[1] 王彦平[1] 李楚杰[1] 

机构地区：[1]暨南大学医学院病理生理教研室发热研究室

出　　处：《中国病理生理杂志》1998年第6期576-578,共3页Chinese Journal of Pathophysiology

摘　　要：目的：观察α－黑素细胞刺激素（α－ＭＳＨ）对内毒素（ＥＴ）发热效应及下丘脑组织环一磷酸腺苷（ｃＡＭＰ）含量的影响。结果：α－ＭＳＨ能明显抑制ＥＴ引起的体温升高（Ｐ＜００５），同时降低ＥＴ引起的下丘脑组织ｃＡＭＰ含量的升高（Ｐ＜００１）；而对正常家兔体温及下丘脑组织ｃＡＭＰ含量均无影响（Ｐ＞００５）。结论：α－ＭＳＨ抑制中枢发热介质ｃＡＭＰ的生成可能是降低ＥＴ发热效应的主要机制之一。从而证明发热时中枢神经不但存在正调节途径，也存在负调节途径。Abstract AIM:To observe the effect of α-MSH on ET-induced fever and hypothalamic content of cAMP in rabbits. RESULTS:Intracerebroventricular injection of α-MSH could suppress febrile response ( P <0 05) and decrease the cAMP content in hypothalamus induced by i.v.injection of ET ( P <0 01),while it did not affect temperature and cAMP content in hypothalamus ( P >0 05) of normal animal.CONCLUSION: The inhibitory effect of α-MSH on synthesis of cAMP in hypothalamus in response to ET might be one of the mechanisms of lowing ET-induced fever, suggesting the possibility that the level of febrile response depend on the interaction between positive and negative pathway. MeSH Endotoxin; Fever; Melanocyte-stimulating hormone

关 键 词：内毒素 发热 Α-MSH 下丘脑 CAMP 

分 类 号：R364.6[医药卫生—病理学]