牛磺酸对大鼠创伤脊髓的保护作用  

Protective role of taurine on spinal cord after trauma

作　　者：王吉先[1] 李燕[1] 王强庆[1] 刘兰英[1] 叶赤[2] 常英姿[2] 陈魁 唐朝枢[2] 

机构地区：[1]山东铝业公司职工医院骨科 [2]北京医科大学心血管研究所

出　　处：《中国病理生理杂志》1998年第6期748-750,共3页Chinese Journal of Pathophysiology

摘　　要：目的：探讨牛磺酸对大鼠创伤脊髓的保护作用。方法：７２只雄性Ｗｉｓｔａｒ大鼠以改良Ａｌｅｎ法（５０ｇｃｍ）打击脊髓致脊髓损伤。结果：牛磺酸可明显减轻脑脊液蛋白漏出（０６６±０１７ｖｓ１２１±０４５ｇ／Ｌ，Ｐ＜００５）和组织水肿（湿重／干重比值３３９±０１２ｖｓ３５３±０１６，Ｐ＜００１）；减少组织ＭＤＡ生成（２４８２２±１２９５ｖｓ２９９４５±４３５２ｎｍｏｌ／ｇｄｗ，Ｐ＜００５）；减轻组织Ｃａ２＋负荷（１３８３５±３２９３ｖｓ１９６６２±４８６１ｐｍｏｌ／ｇｄｗ，Ｐ＜００１）；降低血浆内皮素含量（１６４３±２９７ｖｓ２０３８±３４０ｎｇ／Ｌ，Ｐ＜００５）。结论：牛磺酸可能通过清除氧自由基、稳定细胞膜，防止钙超载和调整血管内源性血管活性物质发挥其保护作用。Abstract AIM:To investigate the protective role of taurine on spinal cord of rats after trauma.METHODS:The rats conflicted to spinal cord contusion ty using a modified Allen's method with 50gcm.RESULTS:The results showed that in comparison with the trauma group,taurine could significantly alleviate the leakage of protein into cerebrospinal fluid(0.66±0 17 vs 1.21±0 45 g/L, P <0 05),decrease tissue edema(wet/dry:3.39±0 12 vs 3.53±0.16, P <0 01) and MDA production(248.22±12 95 vs 299.45±43.52 nmol/gdw, P <0 05),reduce calcium content(138.35±32.93 vs 196.62±48.61 pmol/g dw, P <0 01), and lower plasma endothelin(16.42±2.97 vs 20.38±3.40 ng/L, P <0 05) CONCLUSION:The mechanism of protective action of taurine may be due to oxygen free radical scavenger,membrane stabilization,and regulation of endogenous vasoactive substances. MeSH Taurine;Spinal cord;Wounds and injuries

关 键 词：牛磺酸 脊髓损伤 氧自由基 辅助疗法 

分 类 号：R651.205[医药卫生—外科学]