TEBA催化合成非诺贝特酸  

Catalytic Synthesis of Fenofibrate Acid by TEBA

作　　者：乔德阳[1] 李敢[2] 

机构地区：[1]徐州工业职业技术学院,江苏徐州221140 [2]江苏恩华药业股份有限公司,江苏徐州221007

出　　处：《合成化学》2009年第6期759-760,共2页Chinese Journal of Synthetic Chemistry

摘　　要：在50%氢氧化钾溶液中,4-羟基-4′-氯二苯甲酮(1),氯仿和丙酮在相转移催化剂TEBA的催化下发生缩合反应合成了非诺贝特酸。最佳反应条件为:130g,丙酮120g,TEBA2.5g,氯仿40g,于30℃滴加氯仿,产率89.7%。Fenofibrate acid was synthesized by the condensation reaction of 4-hydroxy-4′-chlorobenzophenone（1） with chloroform and acetone in 50% KOH solution using TEBA as the phase-transfer catalyst. The optimum reaction conditions were as follows： 1 was 30 g; TEBA was 2.5 g; chloroform （ adding dropwise at 30 ℃ ） was 40 g; acetone was 120 g. The yield was 89.7% under the optimum reaction conditions.

关 键 词：非诺贝特酸 相转移催化 药物合成 

分 类 号：R914.5[医药卫生—药物化学] O623.6[医药卫生—药学]