还原耦联法合成β-胡萝卜素  

Synthesis of the β- carotene by the method for the reductive coupling of carbonyls to olefins

作　　者：范桂香 

机构地区：[1]厦门金达威集团股份有限公司,福建厦门361022

出　　处：《化学工程与装备》2009年第11期21-25,共5页Chemical Engineering & Equipment

摘　　要：研究还原耦联法合成β-胡萝卜素。以维生素A醛为原料,通过过渡金属与维生素A醛在一起,金属本身氧化,维生素A醛的羰基还原并耦联成双键,得到β-胡萝卜素产品。在研究还原耦联制备β-胡萝卜素的过程中,对过渡金属钛试剂制成溶剂化试剂进行探讨,解决了钛试剂的稳定性问题,并提高了过渡金属的耦合能力;对还原剂进行活化,提高了还原剂的还原能力;在还原耦联反应中添加氯硅烷,达到催化产生羰基耦联反应的目的。结果表明,合成的β-胡萝卜素含量达到98%以上,收率达到80%以上。Synthesis of the β- carotene by the method for the reductive coupling of carbonyls to olefins is discussed in the article. β- Carotene is prepared by transition metal with retinal, the metal oneself oxidation, the carbonyl group of the retinal is deoxidized and is coupled. Solvation of transition metal is discussed, the stability of the Ti reagent has been resolved, the ability oftbe coupling has been advanced. The ability of the deoxidization is advanced by activation of reducing agent. The coupling reaction of carbonyls is catalysed by appending chlorosilane. The result indicated, the content of β- carotene over 98%, yield over 80%.

关 键 词：Β-胡萝卜素 还原耦联反应 低价钛试剂 还原剂 

分 类 号：TQ611[化学工程—精细化工]