肺表面活性物质相关蛋白A在肺癌组织中的表达及意义  

Expression of surfactant protein A in lung carcinoma and its clinical significance

作　　者：况丽平[1] 吴名耀[2] 

机构地区：[1]广东省汕头市中心医院病理科,515031 [2]汕头大学医学院病理教研室,广东515031

出　　处：《国际检验医学杂志》2009年第11期1072-1073,1076,共3页International Journal of Laboratory Medicine

摘　　要：目的研究肺表面活性物质相关蛋白A(SP-A)在肺腺癌和鳞状细胞癌组织中的表达及其临床意义。方法应用免疫组化En Vision二步法,检测27例肺腺癌、15例鳞状细胞癌组织中SP-A的表达,并分析其与临床病理诸因素之间的关系。结果SP-A在肺腺癌、鳞状细胞癌组织中的阳性表达率分别为51.85%、6.67%,腺癌组织中SP-A的表达明显高于鳞状细胞癌组织(P<0.01)。SP-A在乳头状腺癌、细支气管肺泡癌、腺泡性腺癌和黏液性腺癌组织中的表达率依次为85.71%、50%、40%和25%。SP-A的表达与患者性别、年龄、肿瘤直径大小和淋巴结转移均无关。结论SPA的表达可能与肺癌的组织学类型有关,可作为鉴别肺腺癌与鳞状细胞癌的参考指标。Objective To investigate the expression of surfactant protein A（SP-A） in adenocar cinoma and squamous cell carcinoma of lung and its clinical significance. Methods The expression of SP-A was determined by immunohistoehemical assay （EnVision） in 27 cases of adenocareinoma, 15 ca ses of squamous cell carcinoma of lung. Then the association of SPA expression with clinicopathological parameters was analyzed. Results The expression rate of SPA was significantly higher in adenocarcinoma of lung than that in squamous cell carcinoma of lung （51.85% vs 6.67%, P〈0.01）. The expression rate of SPA in papillary adenocarcinoma, bronchioloalveolar carcinoma, acinar adenocarci noma and musinous adenocarcinoma of lung was respectively 85. 71%, 50%, 40% and 25% . There was no correlation between the expression of SP-A and gender, age, tumor size and lymph node metastasia. Conclusion The expression of SP-A may he associated with histological types of the lung carcinoma, which may be used as important marker in differential diagnosis of adenocarcinoma and squamous cell carcinoma of lung.

关 键 词：肺肿瘤 肺表面活性物质相关蛋白质A 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]