SDF-1／CXCR4轴在内皮祖细胞治疗脑缺血中的作用  

Role of SDF-1/CXCR4 axis in treatment of cerebral ischemia with endothelial progenitor cells

作　　者：张珊珊[1] 罗勇[1] 

机构地区：[1]重庆医科大学附属第一医院神经内科,400016

出　　处：《国际脑血管病杂志》2009年第10期792-796,共5页International Journal of Cerebrovascular Diseases

基　　金：重庆市卫生局中医药科研项目（渝中区2005-B-24）

摘　　要：近年来的研究表明，SDF-1／CXCR4轴在血管形成过程中起着重要作用。脑缺血时，缺血组织内的基质细胞衍生因子（stromal cell—derixed factor，SDF）一1表达增加，其与内皮祖细胞（endothelial progenitor cell，EPC）表面的CXCR4受体结合，进而促进骨髓EPC的动员、增殖并向缺血区迁移和归巢。EPC能在缺血区分化为成熟的血管内皮细胞，促进新血管形成，从而改善缺血组织的血液供应。文章就SDF-1／CXCR4轴在EPC治疗脑缺血中作用进行了综述。Studies in recent years have demonstrated that stromal cell-derived factor-1 （SDF-1）/CXCR4 axis plays an important role in the process of angiogenesis. The expression of SDF-1 in ischemic tissue increases during cerebral ischemia. It binds to CXCR4 receptor on the surface of endothelial progenitor cells （EPCs）, and thus promotes bone marrow-derived EPC mobilization, proliferation, and migration to the ischemic areas and homing. EPCs differentiate into mature erttothelial cells in the ischemic region, promote the formation of new blood vessels, and thus improve the blood supply to ischemic tissue. This article reviews the effect of SDF-1/CXCR4 axis in the treatment of cerebral ischemia with EPCs

关 键 词：趋化因子CXCL12 受体 CXCR4 内皮细胞 干细胞 脑缺血 

分 类 号：R743.3[医药卫生—神经病学与精神病学]