间皮素Mesothelin对大鼠胰岛结构形成和重塑作用的研究进展  

The function of Mesothelin during rat islet architecture formation and remodeling

作　　者：柯星[1] 梁小弟[1] 德伟[1] 

机构地区：[1]南京医科大学生物化学与分子生物学系,江苏南京210029

出　　处：《现代生物医学进展》2009年第19期3757-3759,3767,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金(No.30670781)

摘　　要：大鼠胰腺发育的过程分为以细胞增生、分化为主的早中期及以结构形成、功能完善为主的后期这两个阶段,后期涉及胚胎后期胰岛结构形成和生后胰岛结构重塑。而β细胞的功能完善需要多种细胞迁移和细胞间支持黏附因子的介导,其中表达于β细胞的间皮素(Mesothelin)对细胞间的信号识别以及相互黏附有重要的作用。Mesothelin也是胰腺癌等多种恶性肿瘤的细胞表面标记物。有关Mesothelin在大鼠胰岛结构形成和结构重塑过程中的作用及其与胰腺癌形成关系的作用正处于研究之中。The development of pancreatic islets of rats is divided into two phases： the early-medium phase and the late one.Predominant features are cellular proliferation and differentiation while architectural formation in the early-medium phase.Functional achievement are developed during the late-medium phase.The structural formation occurs during the phase of late embryo and the structural remodeling dose after birth.It is believed that the functional achievement of β-cells is regulated by migration of many kinds of cells and adhesion molecules. Among them Mesothelin which is expressed on the surface of β-cells is very important for recognition of information of cells and cellular adhesion. Mesothelin is also the surface maker of many kinds of malignant cells such as the cells of pancreatic carcinoma. The roles and significances that Mesothelin played in the process for formation and structural remodeling of islets of rats and in the development of pancreatic carcinoma are in investigated.

关 键 词：MESOTHELIN 胰岛结构形成 胰岛结构重塑 细胞迁移黏附 

分 类 号：Q75[生物学—分子生物学] Q786