云南高校图书馆联盟文献共享服务平台- MESOTHELIN

MESOTHELIN: 作品数：26被引量：72H指数：5; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：德伟邵成伟侯良芹李兆申朱庆云更多>>; 相关机构：第二军医大学上海恒润达生生物科技有限公司南京医科大学上海恒润达生生物科技股份有限公司更多>>; 相关期刊：《生物技术进展》《Journal of Hainan Medical University》《中国医药生物技术》《Cellular & Molecular Immunology》更多>>; 相关基金：国家自然科学基金江苏省应用基础研究计划上海市基础研究重大（重点）项目南京医科大学科技发展基金更多>>

T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin: 《Acta Pharmacologica Sinica》2024年第10期2186-2198,共13页Jun-jun Liu Zhi-di Pan Ya-li Yue Shu-sheng Wang Jie Chen Hua Jiang Bao-hong Zhang Ming-yuan Wu Yun-sheng Yuan Yan-lin Bian Hai-yang Yin Lei Wang Jun-yan Li John Gilly Yue-qing Xie Jian-wei Zhu; supported by the National Natural Science Foundation of China(Grant No.81773621 and 82073751 to JWZ);the National Science and Technology Major Project“Key New Drug Creation and Manufacturing Program”of China(Grant No.2019ZX09732001-019 to JWZ).; T cell engaging bispecific antibodies(TCBs)have recently become significant in cancer treatment.In this study we developed MSLN490,a novel TCB designed to target mesothelin(MSLN),a glycosylphosphatidylinositol(GPI)-li...; 关键词：solid tumors T cell engaging bispecific antibodies MSLN490 MESOTHELIN PACLITAXEL

Mesothelin对乳腺癌细胞MDA-MB-231生物学行为的影响: 《天津医药》2023年第10期1032-1039,共8页李宇翔李葛高振芳侯春梅韩根成孙慧燕王立生; 国家自然科学基金资助项目(82301992);科技创新2030-“脑科学与类脑研究”重大项目(2021ZD0201600);河北省重点研发计划资助项目(19272405D)。; 目的探讨间皮素(Mesothelin)对三阴性乳腺癌(TNBC)细胞增殖、凋亡、迁移及侵袭能力的影响。方法免疫化学染色检测TNBC组织、癌旁组织及乳腺癌细胞系中Mesothelin的表达。将过表达Mesothelin慢病毒质粒(Mesothelin组)及对照Scramble质粒(...; 关键词：三阴性乳腺癌细胞增殖细胞凋亡细胞运动间皮素

Mesothelin targeted nano-system enhanced chemodynamic therapy and tirapazamine chemotherapy via lactate depletion被引量：1: 《Nano Research》2023年第5期7108-7118,共11页Guodong Cao Wei Cao Jiawei Zhang Qing Chen Junjie Chen Qiang Chu Qiang Sun Maoming Xiong Bo Chen Xiang Li; the mission book of promotion program of basic and clinical collaborative research of Anhui Medical University(No.2022xkjT028);Anhui Provincial Scientific Research Preparation Plan Project(No.2022AH051171);the Anhui Provincial Natural Science Foundation(No.2208085MH240);Postgraduates of Colleges and Universities in Anhui Province(No.YJS20210308);the National Natural Science Foundation of China(No.81602425);the Anhui Quality Engineering Project(Nos.2020jyxm0898,2020jyxm0910,and 2019kfkc334);the Anhui Medical University Clinical Research Project(No.2020xkj176);the Anhui Health Soft Science Research Project(No.2020WR01003);the Key Research and Development Program of Anhui Province(No.201904a07020045).; The enhanced permeability and retention(EPR)effect alone is not enough for nanoparticles to reach the target.Combination of active and passive targeting may be an effective drug delivery route.Hollow ferric-tannic aci...; 关键词：MESOTHELIN lactate oxidase tumor metastasis synergetic cancer therapy chemodynamic therapy

Phase I study of CAR-T cells with PD-1 and TCR disruption in mesothelin-positive solid tumors被引量：16: 《Cellular & Molecular Immunology》2021年第9期2188-2198,共11页Zhenguang Wang Na Li Kaichao Feng Meixia Chen Yan Zhang Yang Liu Qingming Yang Jing Nie Na Tang Xingying Zhang Chen Cheng Lianjun Shen Jiaping He Xun Ye Wei Cao Haoyi Wang Weidong Han; This research was supported by grants from the National Key Research and Development Program of China(No.2019YFC1316205 to J.N.);National Natural Science Foundation of China(Nos.31991171 and 81830002 to W.D.H.,81773269 and 31722036 to H.Y.W.);Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA16010503 to H.Y.W.).; Programmed cell death protein-1(PD-1)-mediated immunosuppression has been proposed to contribute to the limited clinical efficacy of chimeric antigen receptor T(CAR-T)cells in solid tumors.We generated PD-1 and T cell...; 关键词：CAR-T CRISPR-Cas9 PD-1 TCR MESOTHELIN

结直肠CAR-T细胞治疗相关肿瘤靶点的筛选：CEA、EGFR、HER2、Mesothelin、MUC1和EpCAM的表达及共表达状况被引量：3: 《消化肿瘤杂志（电子版）》2019年第3期225-230,共6页胡阿锦张畅龚苗子王云帆王跃王淑芳张雨缪琦崔朝丽张晋夏; 目的分析CEA、EGFR等肿瘤相关抗原作为CAR-T治疗靶点在结直肠癌中的分布。方法回顾并选取2014年-2017年的122例结直肠癌病例,应用免疫组织化学法检测肿瘤相关抗原CEA、EGFR、HER2、Mesothelin、MUC1和EpCAM在结直肠癌组织中蛋白表达范...; 关键词：结直肠癌 CAR-T 肿瘤相关抗原免疫组织化学法

人源化Mesothelin嵌合抗原受体介导的T细胞抗肿瘤效果被引量：1: 《生物技术进展》2019年第3期253-261,共9页刘圆圆牛卿冯晓明; 国家自然科学基金项目(81670107;81870090)资助; CAR-T细胞(嵌合抗原受体T细胞)在治疗血液肿瘤领域已取得了显著的效果,但在实体瘤中的治疗应用仍存在很多阻碍。间皮素(Mesothelin)是肿瘤相关抗原,在间皮瘤、卵巢癌、胰腺癌等肿瘤细胞表面过表达,当前大多以Mesothelin为靶点的研究使...; 关键词：间皮素人源化scFv CAR-T 实体瘤

间皮素与肿瘤靶向治疗: 《中国医药生物技术》2019年第3期258-262,共5页段爱军苗庆芳; 中国医学科学院医学与健康科技创新工程(2016-I2M-3-013); 间皮素(mesothelin,MSLN)是一种细胞表面糖蛋白,在正常组织中很少表达,但在卵巢癌、胰腺癌和恶性间皮瘤等肿瘤组织中高表达[1],因此间皮素有望成为癌症治疗的重要靶点。由于间皮素基因敲除小鼠未发现表型异常,所以间皮素的生物学功能目...; 关键词：靶向治疗肿瘤组织间皮素 MESOTHELIN 肿瘤细胞增殖基因敲除小鼠表面糖蛋白恶性间皮瘤

Antibody drug conjugate development in gastrointestinal cancers:hopes and hurdles from clinical trials: 《Cancer Drug Resistance》2018年第4期204-218,共15页Xiaorong Wu Thomas Kilpatrick Ian Chau; Gastrointestinal(GI)cancers represent the leading cause of cancer-related mortality worldwide.Antibody drug conjugates(ADCs)are a rapidly growing new class of anti-cancer agents which may improve GI cancer patient sur...; 关键词：Antibody drug conjugates human epidermal growth receptor 2 MESOTHELIN guanylyl cyclase C carcinogenic antigen-related cell adhesion molecule 5 gastric cancer colorectal cancer pancreatic cancer T-DM1 DS-8201a

Correlation of serum mesothelin and human epididymis secretory protein 4 contents with cellular infiltrative growth in patients with ovarian cancer: 《Journal of Hainan Medical University》2017年第18期136-139,共4页Hong-Lin Sun Shu-Kai Sun; Objective: To study the correlation of serum mesothelin and human epididymis secretory protein 4 contents with cellular infiltrative growth in patients with ovarian cancer. Methods:Patients with ovarian cancer who und...; 关键词：OVARIAN cancer MESOTHELIN Human EPIDIDYMIS SECRETORY protein 4 Proliferation Invasion

Clinical impacts of mesothelin expression in gastrointestinal carcinomas被引量：4: 《World Journal of Gastrointestinal Pathophysiology》2016年第2期218-222,共5页Takahiro Einama Futoshi Kawamata Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Fumihiko Matsuzawa Tatsuzo Mizukami Yuji Konishi Munenori Tahara Toshiya Kamiyama Okio Hino Akinobu Taketomi Satoru Todo; Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpress...; 关键词：MESOTHELIN LUMINAL membrane EXPRESSION CYTOPLASMIC EXPRESSION Tumor marker Cancer therapy

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