Correlation of serum mesothelin and human epididymis secretory protein 4 contents with cellular infiltrative growth in patients with ovarian cancer  

作　　者：Hong-Lin Sun Shu-Kai Sun 

机构地区：[1]Department of Laboratory Medicine,China University of Petroleum(East China)Hospital in Shandong Province,Qingdao City,Shandong Province,266580 [2]Department of Laboratory Medicine,West Coast Medical Center of the Affiliated Hospital of Qingdao University in Shandong Province,Qingdao City,Shandong Province,266555

出　　处：《Journal of Hainan Medical University》2017年第18期136-139,共4页海南医学院学报（英文版）

摘　　要：Objective: To study the correlation of serum mesothelin and human epididymis secretory protein 4 contents with cellular infiltrative growth in patients with ovarian cancer. Methods:Patients with ovarian cancer who underwent surgical resection in West Coast Medical Center of the Affiliated Hospital of Qingdao University between June 2013 and December 2016 were selected as the ovarian cancer group of the study, and healthy women who received physical examination in China University of Petroleum (East China) Hospital during the same period were selected as the control group of the study. Serum was collected from two groups of subjects to detect serum mesothelin and human epididymis secretory protein 4 contents, and the ovarian cancer lesions and adjacent lesions were collected from ovarian cancer group to detect the expression of proliferation, apoptosis and invasion genes. Results: Serum mesothelin and human epididymis secretory protein 4 contents of ovarian cancer group were significantly higher than those of control group;FUNDC1, LSD1, TNFAIP8, CXCR4, β-catenin, CD44, PELP1, Slug, ZEB1 and Snail mRNA expression in ovarian cancer lesions were significantly higher than those in adjacent lesions and positively correlated with serum mesothelin and human epididymis secretory protein 4 contents while MFN2, PTEN, FN14 and E-cadherin mRNA expression were significantly lower than those in adjacent lesions and negatively correlated with serum mesothelin and human epididymis secretory protein 4 contents. Conclusion: Serum mesothelin and human epididymis secretory protein 4 contents abnormally increase in patients with ovarian cancer and are associated with the infiltrative growth of cancer cells.

关 键 词：OVARIAN cancer MESOTHELIN Human EPIDIDYMIS SECRETORY protein 4 Proliferation Invasion 

分 类 号：R73[医药卫生—肿瘤]