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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression
《Neural Regeneration Research》2025年第11期3259-3272,共14页Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni Li Haojie An Shiyi Zeng Chunyan Wang Li Yang Cheng Long 
supported by the National Natural Science Foundation of China,Nos.32371065(to CL)and 32170950(to LY);the Natural Science Foundation of the Guangdong Province,No.2023A1515010899(to CL);the Science and Technology Projects in Guangzhou,Nos.2023A4J0578 and 2024A03J0180(to CW)。
Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-...
关键词：basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission 
Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain
《Neural Regeneration Research》2025年第9期2682-2696,共15页Xiaoyu Zhang Yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina Huang Zifeng Xu 
supported by the National Natural Science Foundation of China,Nos.82001178(to LW),81901129(to LH),82001175(to FX);Shanghai Sailing Program,No.20YF1439200(to LW);the Natural Science Foundation of Shanghai,China,No.23ZR1450800(to LH);and the Fundamental Research Funds for the Central Universities,No.YG2023LC15(to ZX)。
Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein ...
关键词：dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons 
HMGN2 accelerates the proliferation and cell cycle progression of glioblastoma by regulating CDC20 expression
《Genes & Diseases》2025年第3期492-507,共16页Jiacheng Zhong Shuang Shi Wen Peng Hongjuan Cui Xiaochuan Sun 
Gliomas represent the most common primary malignant intracranial tumors in adults.Despite recent advances in treatment,the prognosis of patients with glioblastoma remains poor.Epigenetic abnormalities,the hallmarks of...
关键词：CDC20 Epigenetic regulation GLIOMA Histone acetylation HMGN2 
Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells
《Genes & Diseases》2025年第3期567-583,共17页Jing Zou Chengcheng Du Senrui Liu Piao Zhao Shengqiang Gao Bowen Chen Xiangdong Wu Wei Huang Zhenglin Zhu Junyi Liao 
supported by the Science and Technology Research Program of the Chongqing Education Commission(China)(No.KJQN202100431,KJZDM202100401);supported by the National Natural Science Foundation of China(No.81972069,82002312);CQMU Program for Youth Innovation in Future Medicine(Chongqing,China)(No.W0154);Innovation Project from Chongqing Municipal Education Commission(China)(No.CYB21169);Cultivating Program and Candidate of TipTop Talent of The First Affiliated Hospital of Chongqing Medical University(Chongqing,China)(No.BJRC2021-04);Cultivating Program of Postdoctoral Research of The First Affiliated Hospital of Chongqing Medical University(Chongqing,China)(No.CYYY-BSHPYXM-202202);Special Support from Chongqing Postdoctoral Research Program(Chongqing,China)(No.2021XM1029);upported by a postdoctoral fellowship from Chongqing Medical University and rewarded by China Postdoctoral Science Foundation(No.2022M720605).
Although bone morphogenetic protein 2 (BMP2) can induce chondrogenic differentiation of mesenchymal stem cells (MSCs), its induction of endochondral ossification limits theapplication of BMP2-based cartilage regenerat...
关键词：BMP2 Chondrogenic differentiation Endochondral ossification Mesenchymal stem cells Notch1 signaling 
Rates of p16 and p53 expression in head and neck cutaneous squamous cell carcinoma vary according to human papillomavirus status
《World Journal of Clinical Cases》2025年第18期1-4,共4页Rachid Ait Addi 
The strong association between human papillomavirus(HPV)infection and oropharyngeal squamous cell carcinoma(SCC)is well-documented,with p16 expression serving as a reliable predictor of HPV involvement.HPV-related tum...
关键词：Squamous cell carcinoma OROPHARYNGEAL Non-oropharyngeal Human papillomavirus P16 P53 
Actin polymerization regulates the osteogenesis of hAsCs by influencingα-tubulin expression and Eg5 activity
《Genes & Diseases》2025年第2期29-32,共4页Tingyu Fan Wenqing Liu Rongmei Qu Jinhui Zhu Yulian Shi Jiaxuan Liu Xiangtian Li Zhitao Zhou Yunbing Chang Jun Ouyang Jingxing Daia 
supported by the National Key R&D Program of China (No.2022YFF1202603);the President's Foundation of TCM-Integrated Hospital of Southern Medical University (No.1202103001).
Seed cells,scaffold materials,and growth factors constitute the three fundamental components of bone tissue engineering.In recent years,human adipose-derived stem cells(hASCs)have emerged as promising candidate cells ...
关键词：Eg5 engineering. CONSTITUTE 
TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing ERαexpression in triple-negative breast cancer
《Genes & Diseases》2025年第2期37-40,共4页Shang Gao Ping Sun Zekun Wang Yecheng Jin Wenjie Sun Xi Li Ruonan Duan Jiangxia Li Qiji Liu 
supported by grants from the National Key R&D Program of China (No.2022YFC2703701 to Qiji Liu);the National Natural Science Foundation of China (No.82271901,32070586);the Shandong Provincial Natural Science Foundation,China (No.ZR2020MH086);Taishan Scholar Program of Shandong Province (tsqn202211318);NHC Key Laboratory of Birth Defects Prevention,China (No.ZD202101).
Triple-negative breast cancer(TNBC)is defined by the lack of estrogen receptor(ER),progesterone receptor,and amplified human epidermal growth factor receptor expression.TNBC accounts for~15%of all breast cancer cases ...
关键词：expression. BREAST cancer 
Molecular Mechanism Study on the Expression of TF-MPs in Cervical Cancer Patients and Deep Venous Thrombosis
《Journal of Clinical and Nursing Research》2025年第3期120-125,共6页Qingrong Hu Jin Li Kedan Liu 
Correlation analysis between TF-MPs expression level and deep vein thrombosis in patients with cervical cancer(Project No.:2023-ZD-69)。
Objective:To explore the molecular mechanism of tissue factor-positive microparticles(TF-MPs)expression and deep venous thrombosis(DVT)in patients with cervical cancer.Methods:A total of 200 patients with cervical can...
关键词：Cervical cancer TF-MPs Deep venous thrombosis Molecular mechanism 
High cellular prion protein expression in cholangiocarcinoma:A marker for early postoperative recurrence and unfavorable prognosis
《World Journal of Gastrointestinal Surgery》2025年第3期267-277,共11页Dong Woo Shin Yoon Ah Cho Sung-Hoon Moon Tae Hyung Kim Ji-Won Park Jung-Woo Lee Ji-Young Choe Min-Jeong Kim Sung-Eun Kim 
Supported by National Research Foundation of Korea Grant Funded by the Korea Government,No.RS-2023-00213951.
BACKGROUND The cellular prion protein(PrPC),traditionally associated with neurodegenerative disorders,plays an important role in cancer progression and metastasis by inhibiting apoptosis.AIM To investigate the influen...
关键词：CHOLANGIOCARCINOMA Cellular prion protein Liver neoplasms PROGNOSIS RECURRENCE SURVIVAL 
Research on the Integration Path of Ideological and Political Education in the Design Thinking and Expression Course
《Journal of Contemporary Educational Research》2025年第3期17-24,共8页Bing Su Qin Tong Yue Ma Hongsheng Wang 
“Curriculum Ideological and Political Education”Demonstration Project of Chongqing University of Posts and Telecommunications:Design Thinking and Expression(Environmental Design)(XKCSZ2251);Construction and Practice of the Ability Training System for“Internet+”Design Talents to Serve Rural Revitalization(233231)。
This study explores the integration path of ideological and political education in the course Design Thinking and Expression of environmental art design,aiming to enhance students’innovative thinking,social responsib...
关键词：Ideological and political education Design Thinking and Expression course Integration path 
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