蛛网膜下腔出血性脑血管痉挛动物模型的制作  

Establishment of an animal model of cerebral vasospasm following subarachnoid hemorrhage

作　　者：贾莉[1] 孙保亮[2] 张磊[3] 

机构地区：[1]济宁医学院临床学院诊断学教研室,山东省济宁市272013 [2]泰山医学院附属医院神经内科,山东省泰安市271000 [3]金乡县人民医院神经内科,山东省济宁市272200

出　　处：《中国组织工程研究与临床康复》2009年第41期8147-8150,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金资助项目(30570651;30670724);泰安市大学生科技创新行动计划项目(2006D1082)~~

摘　　要：蛛网膜下腔出血引起的脑血管痉挛是导致蛛网膜下腔出血患者不良预后的主要原因之一,其发生机制至今尚未完全明了。因此,建立一种理想的蛛网膜下腔出血性脑血管痉挛动物模型将对脑血管痉挛发生机制及临床防治的研究起到巨大的推动作用。文章介绍了各种蛛网膜下腔出血性脑血管痉挛动物模型的制作方法、优缺点及应用范围,但目前尚无一种用于研究蛛网膜下腔出血后症状性脑血管痉挛的理想模型。Cerebral vasospasm caused by subarachnoid hemorrhage is a major cause of poor prognosis, but the pathogenesis has not been understood completely until now. Therefore, to found an ideal animal model of cerebral vasospasm following subarachnoid hemorrhage will have an enormous advanced effect on research of pathogenesis, clinical prevention and cure of cerebral vasospasm. The author reviewed various establishment methods of animal models of cerebral vasospasm following subarachnoid hemorrhage, and their advantages, disadvantages and application. However, there is still not a model used for studying symptomatic cerebral vasospasm following subarachnoid hemorrhage

关 键 词：蛛网膜下腔出血 脑血管痉挛 动物模型 

分 类 号：R-332[医药卫生]