直肠癌直肠系膜转移相关因素的临床研究  

Relevant factors of mesorectal lymph node metastasis in rectal carcinoma.

作　　者：彭勃[1] 黎明[1] 谢权[1] 张罡[1] 

机构地区：[1]中南大学湘雅医学院附属海口医院普外科,海南海口570208

出　　处：《海南医学》2009年第12期12-14,共3页Hainan Medical Journal

摘　　要：目的探讨直肠癌系膜淋巴结转移的规律及与临床病理特征的关系。方法回顾性分析2006年1月至2009年6月在我院以全直肠系膜切除(Total mesorectal excision,TME)原则行直肠癌根治术的47例直肠癌临床资料,采用卡方检验、非参数秩和检验及Logistic多因素回归分析,了解其淋巴结转移与临床病理之间的关系。结果患者的性别、年龄,肿瘤大小、部位、侵犯肠管周径,术前CEA表达水平与直肠系膜淋巴结转移无明显关系(P>0.05)。肿瘤的分化程度、浸润深度与直肠系膜淋巴结转移相关,低分化肿瘤的直肠系膜转移阳性率明显高于高、中分化组(P<0.05)。多因素回归分析显示肿瘤的分化程度与直肠系膜的淋巴结转移相关。结论直肠癌直肠系膜淋巴结转移与肿瘤的分化程度相关。Objective To investigate the characteristic of mesorectal lymph node metastasis and evaluate the relationship with clinicopathologic characteristics. Methods To analyse retrospectively the clinic data of 47 patients who had received radical surgery of rectal cancer and total mesorectal excision from Jan. 2006 to Jun. 2009. The associations between lymphatic metastasis and chnicopathologic variables were evaluated by Chi - squared test, no - parameter rank sum test and logistic regression. Results No significant correlation were found between mesorectal metastasis and other variables such as gender, age, tumor size, the location of tumor, the diameter of affected bowel, the level of preoperative CEA expression. There was significant correlation between mesorectal metastasis and the depth of tumor invasion, tumor differentiating degree, and the rate of mesorectal metastasis in poorly differ- entiated group was higher than that in well and moderately differentiated group（ P 〈 0.05 ）. Logistic regression anal- ysis showed that mesorectal lymph node metastasis was related to tumor differentiating degree. Conclusion The mesorectal lymph node metastasis is related to tumor differentiating degree.

关 键 词：直肠癌 直肠系膜 淋巴结转移 

分 类 号：R735.37[医药卫生—肿瘤]