急性脑梗死早期血清中OX-LDL、HS-CRP含量水平与APACHEⅡ的关系  

The Relationship of Serum OX-LDL,HS-CRP Level with APACHEⅡ in the Patients with Acute Cerebral Infarction in the Early Phase

作　　者：张晓明[1] 李新立[1] 夏强[1] 徐明义[1] 刘群才[1] 

机构地区：[1]中国人民解放军第159医院神经内科,河南驻马店463008

出　　处：《包头医学院学报》2009年第5期52-53,共2页Journal of Baotou Medical College

摘　　要：目的:探讨血清氧化低密度脂蛋白(OX-LDL)、高敏C-反应蛋白(HS-CRP)在急性脑梗死(ACI)患者含量水平的变化,观察OX-LDL、HS-CRP含量水平与急性生理学及慢性健康状况(APACHEⅡ)评分的关系。方法:采用酶联免疫吸附试验、微粒化增强免疫固定试验测定215例ACI患者入院第2天血清中OX-LDL、HS-CRP含量水平,并与30例健康者(对照组)作对照。同时进行APACHEⅡ评分,比较不同APACHEⅡ分值血清中OX-LDL、HS-CRP含量水平。结果:ACI患者入院第2天血清中OX-LD、HS-CRP含量明显高于对照组(P<0.01);OX-LD、HS-CRP的含量越高,APACHEⅡ评分越高。结论:ACI患者早期血清中OX-LDL、HS-CRP含量水平明显升高,其水平在一定程度上可估计病情和预后。Objective： To explore the changes in serum OX-LD and HS-CRP level in patients with acute cerebral infarction, and to observe the relationship of serum OX-LDL and HS-CRP level with score of APACHEⅡ. Methods： With enzyme linked immaunosorbent ashy （ELISA） and micronize strengthening immunofixation, The serum OX-LDL and HS-CRP level of 215 patients with ACI was measured on the second day after hospitalization. In addition, 30 healthy volunteers were taken as the control group. Meanwhile, the score of APACHEⅡ was evaluated,the serum OX-L and HS-CRP levels in different scores of APACHEⅡ were compared. Results： The serum OX-LDL and HS-CRP levels in the patients with ACI were higher than those in the control group （ P 〈20.01）, The higher the score of APACHEⅡ was , the higher the level of serum OX-LDI and HS-CRP would be （ P〈0. 01）. Conclusion： The serum OX -LDL and HS-CRP levels in the patients with ACI in the early phase were higher than those in the normal, the level of OX-LDL and HS-CRP can be taken, to some degree, as an indicator for the judgment of patients conditions and prognosis.

关 键 词：急性脑梗死 氧化低密度脂蛋白 高敏C-反应蛋白 急性生理学及慢性健康状况评分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]