子宫内膜异位症患者血清VEGFR-1和VEGFR-2水平的检测及其意义  

Measurement and study of circulating levels of VEGF receptors,VEGFR-1 and -2 in Endometriosis

作　　者：顾广宇[1] 蒋创[1] 钱永红[1] 

机构地区：[1]江苏省苏州市立医院本部妇产科,215000

出　　处：《齐齐哈尔医学院学报》2009年第20期2487-2488,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨血管内皮生长因子受体1(VEGFR-1)及血管内皮生长因子受体2(VEGFR-2)在子宫内膜异位症发病机制中的作用及其在评估疾病预后中的意义。方法选择病理确诊的子宫内膜异位症患者共31例及对照组35例患者,分别于术前及术后抽取静脉血测定VEGFR-1和VEG-FR-2的水平进行比较。结果术前内异症组的VEGFR-1及R-2水平均明显高于对照组,且中重组的内异症患者术前血清VEGF受体水平与轻微组比较具有显著性,手术前后VEGFR-1比较内异症组术后较术前下降,而VEGFR-2水平手术前后比较差异无显著性。结论VEGFR-1及VEGFR-2的高表达可能导致了子宫内膜异位症患者异位内膜的侵蚀和异位生长,同时在血清中的高含量为血行远处转移提供了理论支持,术后对VEGFR-1水平的检测有助于明确内异病灶的清除情况。Objective To explore the expression and significance of VEGFR-- 1 and VEGFR--2 in Endometriosis,and their roles in evaluation of the aftersurgical outcome. Methods The expression of serum VEGFR--1 and VEGFR--2 in 31 Endometriosis samples paired with 35 samples of the corresponding normal people were examined by enzyme--linked immunosorbent assay（ELISA）, before and after the operation. Results VEGFR--1,VEGFR--2 expressed to a different degree in EM before operation, （P〈 0.01）. In addition, the expression of VEGFR--1 correlated with the level of r--AFS in EM. After surgery, the circulating level of VEGFR--1 became lower than that of before surgery. But the level of VEGFR--2 had no change. Conclusions The high expression of circulating VEGFR--1 and VEGFR--2 may play an important role in promoting the proliferation and provoking angiogenesis of EM cells.

关 键 词：血管内皮生长因子受体1(VEGFR-1) 血管内皮生长因子受体2(VEGFR-2) 子宫内膜异位症(EM) 血清 

分 类 号：R394.8[医药卫生—医学遗传学] R711.71[医药卫生—基础医学]