环氧化酶-2在膀胱移行细胞癌中的表达及意义  

The expression and significance of cyclooxygenase-2 in bladder transitional cell carcinoma

作　　者：胡运青[1] 孙桂明[2] 李淮岗 王兆光[2] 王磊[4] 

机构地区：[1]安徽省皖南医学院,241007 [2]淮南新康医院泌尿外科 [3]淮南市临床病理中心 [4]淮南新康医院病理科

出　　处：《中国现代药物应用》2009年第23期4-6,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨环氧化酶-2(COX-2)在膀胱移行细胞癌(BTCC)中的表达及其临床意义。方法采用免疫组化S-P法对53例膀胱移行细胞癌和12例正常膀胱黏膜中COX-2的表达,结合临床资料,研究之其间的关系。结果COX-2在正常膀胱黏膜中无表达,膀胱移行细胞癌中阳性表达为66.0%,差异有显著统计学意义(P<0.01),COX-2的表达程度与肿瘤病理分级相关(P<0.05),COX-2在不同病理分期之间的表达水平差异有统计学意义(P<0.01),复发组显著高于无复发组(P<0.01)。结论COX-2阳性表达与膀胱移行细胞癌病理分级、浸润及复发关系密切,可能成为判断膀胱移行细胞癌生物学行为的一个重要指标。Objective To investigate the expression and significance of cyclooxygenase-2 （COX-2）in bladder transitional cell carcinoma（BTCC） and analyze its correlation with the biological behavior of the tumor. Methods 53 cases of BTCC and 12 cases of normal bladder mucosa were detected by the immunohistochemical S-P staining. Results COX-2 was negatively expressed in normal bladder mucosal epithelia and the rate of positive expressions of COX-2 was 66.0% in BTCC group. COX-2 overexpression in G1 ,G2 and G3 were 28.6%, 64. 8% and 85. 0% respectively,which were significantly different（P 〈0. 05）. Statistically significance was also found in different clinical pathological stage （ P 〈 0. 01 ）, which were 59.4% in non-invasive group （ Tis-T1 ） and 85.7% in invasive group （T2-T4）. COX-2 positive expression significantly higher in recurrence than thet in primary BTCC group （ P 〈 0. 01 ）. Conclusion COX-2 positive expression in BTCC is closely associated with tumor grade,invasiveness and recurrence, which may be used as an useful maker for evaluation the biological behaviors of BTCC.

关 键 词：环氧化酶 免疫组织化学 膀胱移行细胞癌 

分 类 号：R737.14[医药卫生—肿瘤] R971.1[医药卫生—临床医学]