核仁形成区蛋白变化与白血病疗效及预后判断的临床观察  

Clinical Observation on the Correlation between Nucleolar Organizer Region Associated Argyrophilia Proteins,Therapeutic Effect and Prognosis of Leukemia

作　　者：杨凌[1] 陆桂君[1] 黎承平[1] 温柏平[1] 李惠民[1] 杨弘[1] 梁瑞琼[1] 

机构地区：[1]昆明医学院第一附属医院血液科

出　　处：《昆明医学院学报》1998年第4期14-16,共3页Journal of Kunming Medical College

摘　　要：对７８例急性白血病和慢性粒细胞白血病患者于化疗前后取其骨髓细胞，应用Ｈｏｗｅｌ一步法［１］嗜银染技术观察其核仁形成区蛋白颗粒（ＡｇＮＯＲｓ）数目及形态变化，并与２２例非血液肿瘤疾病进行对照．结果：急性白血病组及慢性粒细胞白血病组在未缓解期其ＡｇＮＯＲｓ数目明显高于缓解期组（Ｐ＜００１），且颗粒粗大，呈弥散型及巨块型；而已缓解期患者ＡｇＮＯＲｓ数较对照组仍明显增多（Ｐ＜００５）．提示：ＡｇＮＯＲｓ可作为白血病疗效判断。Bone marrow cells were taken from 78 cases of acute and chronic myelogenous leukemia before and after they received chemotherapy.Howell's one-step method was used for AgNORs counts and morphological change.The two indicators were compared with 22 cases of non-hemopathic malignancy tumor.The results showed that in different phase of acute and chronic myelogenous leukemia,an AgNORs count was different.In the non-remission group,AgNORs count was significantly higher than remission group ( P<0 01 ),and displayed coarse,diffuse and chunky granules.AgNORs counts in remission group was higher than control group ( P<0 05 ).Which suggested that AgNORs could be used as an indicator of assessing therapeutic effect and prognosis of leukemia.

关 键 词：核仁形成区蛋白 银染技术 白血病 疗效 预后 

分 类 号：R733.7[医药卫生—肿瘤]